公开(公告)号：US09428455B2

公开(公告)日：2016-08-30

申请号：US14688451

申请日：2015-04-16

Applicant: Pfizer Inc.

Inventor： Renuka Devi Reddy ,  Evgenyi Shalaev ,  Ravi Mysore Shanker ,  Carl Bernard Ziegler

IPC: C07D207/34 ,  A61K31/40

CPC classification number: C07D207/34 ,  A61K31/40

Abstract: Processes for annealing amorphous atorvastatin is described. Pharmaceutical compositions and formulations containing annealed amorphous atorvastatin are also described.

公开(公告)号：US20140155627A1

公开(公告)日：2014-06-05

申请号：US14176081

申请日：2014-02-08

Applicant: Pfizer Inc.

Inventor： Antone John deBettencourt, III ,  Peter Robert Rose ,  Evgenyi Shalaev ,  George Joseph Quallich ,  Carl Bernard Ziegler

IPC: C07D207/34

CPC classification number: C07D207/34 ,  A61K9/145 ,  A61K9/146 ,  A61K9/19 ,  A61K31/40

Abstract: A process for forming amorphous atorvastatin comprising the steps of dissolving atorvastatin in a non-hydroxylic solvent and removing the solvent by freeze-drying, as well as processes of dissolving atorvastatin in a hydroxylic solvent with a solubilizing agent or an alkalizing agent or an antioxidant and removing the solvent by freeze-drying to afford amorphous atorvastatin.

Abstract translation: 一种形成无定形阿托伐他汀的方法，包括以下步骤：将阿托伐他汀溶解在非羟基溶剂中，并通过冷冻干燥除去溶剂，以及将阿托伐他汀溶解在羟基溶剂中，与增溶剂或碱化剂或抗氧化剂，以及 通过冷冻干燥除去溶剂，得到无定形的阿托伐他汀。

公开(公告)号：US09932307B2

公开(公告)日：2018-04-03

申请号：US15220897

申请日：2016-07-27

Applicant: Pfizer Inc.

Inventor： Renuka Devi Reddy ,  Evgenyi Shalaev ,  Ravi Mysore Shanker ,  Carl Bernard Ziegler

IPC: C07D207/34 ,  A61K31/40

CPC classification number: C07D207/34 ,  A61K31/40

Abstract: Processes for annealing amorphous atorvastatin is described. Pharmaceutical compositions and formulations containing annealed amorphous atorvastatin are also described.

公开(公告)号：US20160332965A1

公开(公告)日：2016-11-17

申请号：US15220897

申请日：2016-07-27

Applicant: Pfizer Inc.

Inventor： Renuka Devi Reddy ,  Evgenyi Shalaev ,  Ravi Mysore Shanker ,  Carl Bernard Ziegler

IPC: C07D207/34 ,  A61K31/40

CPC classification number: C07D207/34 ,  A61K31/40

Abstract: Processes for annealing amorphous atorvastatin is described. Pharmaceutical compositions and formulations containing annealed amorphous atorvastatin are also described.

公开(公告)号：US20150274659A1

公开(公告)日：2015-10-01

申请号：US14688451

申请日：2015-04-16

Applicant: Pfizer Inc.

Inventor： Renuka Devi Reddy ,  Evgenyi Shalaev ,  Ravi Mysore Shanker ,  Carl Bernard Ziegler

IPC: C07D207/34

CPC classification number: C07D207/34 ,  A61K31/40

Abstract: Processes for annealing amorphous atorvastatin is described. Pharmaceutical compositions and formulations containing annealed amorphous atorvastatin are also described.

Abstract translation: 描述了退火无定形阿托伐他汀的方法。 还描述了含有退火的无定形阿托伐他汀的药物组合物和制剂。

公开(公告)号：US09056831B2

公开(公告)日：2015-06-16

申请号：US14176081

申请日：2014-02-08

Applicant: Pfizer Inc.

Inventor： Antone John deBettencourt, III ,  Peter Robert Rose ,  Evgenyi Shalaev ,  George Joseph Quallich ,  Carl Bernard Ziegler

IPC: C07D207/00 ,  A61K31/40 ,  C07D207/34 ,  A61K9/14 ,  A61K9/19

CPC classification number: C07D207/34 ,  A61K9/145 ,  A61K9/146 ,  A61K9/19 ,  A61K31/40

Abstract: A process for forming amorphous atorvastatin comprising the steps of dissolving atorvastatin in a non-hydroxylic solvent and removing the solvent by freeze-drying, as well as processes of dissolving atorvastatin in a hydroxylic solvent with a solubilizing agent or an alkalizing agent or an antioxidant and removing the solvent by freeze-drying to afford amorphous atorvastatin.

Abstract translation: 一种形成无定形阿托伐他汀的方法，包括以下步骤：将阿托伐他汀溶解在非羟基溶剂中并通过冷冻干燥除去溶剂，以及将阿托伐他汀溶解在羟基溶剂中与增溶剂或碱化剂或抗氧化剂，以及 通过冷冻干燥除去溶剂，得到无定形的阿托伐他汀。