公开(公告)号：US11065249B2

公开(公告)日：2021-07-20

申请号：US17090619

申请日：2020-11-05

Applicant: Pfizer Inc.

Inventor： David James Edmonds ,  Kevin James Filipski ,  Kentaro Futatsugi ,  Michelle Renee Garnsey ,  Jack Chang Hung Lee ,  Daniel Jonathan Smaltz

IPC: A61K31/506 ,  A61P3/06 ,  A61K31/155 ,  A61K31/4545 ,  A61K31/4985 ,  A61K31/7048 ,  A61K45/06 ,  C07D401/14

Abstract: Described herein are compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are defined herein, their use as diacylglycerol acyltransferase 2 (DGAT2) inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, NASH.

公开(公告)号：US11471458B2

公开(公告)日：2022-10-18

申请号：US17062982

申请日：2020-10-05

Applicant: Pfizer Inc.

Inventor： David James Edmonds ,  Kevin James Filipski ,  Kentaro Futatsugi ,  Michelle Renee Garnsey ,  Jack Chang Hung Lee ,  Daniel Jonathan Smaltz

IPC: A61K31/506 ,  A61P3/06 ,  A61K31/155 ,  A61K31/4545 ,  C07D401/14 ,  A61K31/4985 ,  A61K31/7048 ,  A61K45/06

Abstract: Described herein are compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are defined herein, their use as diacylglycerol acyltransferase 2 (DGAT2) inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, NASH.

公开(公告)号：US20210100798A1

公开(公告)日：2021-04-08

申请号：US17090619

申请日：2020-11-05

Applicant: Pfizer Inc.

Inventor： David James Edmonds ,  Kevin James Filipski ,  Kentaro Futatsugi ,  Michelle Renee Garnsey ,  Jack Chang Hung Lee ,  Daniel Jonathan Smaltz

IPC: A61K31/506 ,  A61K31/4545 ,  A61K31/155 ,  A61K31/7048 ,  A61K31/4985 ,  A61P3/06 ,  C07D401/14 ,  A61K45/06

Abstract: Described herein are compounds of Formula (1) wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are defined herein, their use as diacylglycerol acyltransferase 2 (DGAT2) inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, NASH.

公开(公告)号：US20210100796A1

公开(公告)日：2021-04-08

申请号：US17062982

申请日：2020-10-05

Applicant: Pfizer Inc.

Inventor： David James Edmonds ,  Kevin James Filipski ,  Kentaro Futatsugi ,  Michelle Renee Garnsey ,  Jack Chang Hung Lee ,  Daniel Jonathan Smaltz

IPC: A61K31/506 ,  C07D401/14 ,  A61K45/06 ,  A61P3/06 ,  A61K31/155 ,  A61K31/4985 ,  A61K31/7048 ,  A61K31/4545

Abstract: Described herein are compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are defined herein, their use as diacylglycerol acyltransferase 2 (DGAT2) inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, NASH.