公开(公告)号：US20210069219A1

公开(公告)日：2021-03-11

申请号：US17082102

申请日：2020-10-28

Applicant: Pfizer Inc.

Inventor： Joseph Walter Strohbach ,  Tsutomu Akama ,  David Clive Blakemore ,  Robert Toms Jacobs ,  Peter Jones ,  David Christopher Limburg ,  Martins Sunday Oderinde ,  Matthew Alexander Perry ,  Jacob John Plattner ,  Rubben Federico Torella ,  Yasheen Zhou ,  Thean Yeow Yeoh

IPC: A61K31/69 ,  A61K31/519 ,  C07F5/02

Abstract: The present invention relates to boron containing compounds of Formula (I) X—Y—Z   Formula (I) that inhibit phosphodiesterase 4 (PDE4). The invention also encompasses pharmaceutical compositions containing these compounds and methods for treating diseases, conditions, or disorders ameliorated by inhibition of PDE4.

公开(公告)号：US20230148402A1

公开(公告)日：2023-05-11

申请号：US18066468

申请日：2022-12-15

Applicant: Pfizer Inc.

Inventor： Tsutomu Akama ,  David Clive Blakemore ,  Robert Toms Jacobs ,  Peter Jones ,  David Christopher Limburg ,  Martins Sunday Oderinde ,  Matthew Alexander Perry ,  Jacob John Plattner ,  Joseph Walter Strohbach ,  Rubben Federico Torella ,  Thean Yeow Yeoh ,  Yasheen Zhou

IPC: A61K31/69 ,  A61K31/519 ,  C07F5/02

CPC classification number: A61K31/69 ,  A61K31/519 ,  C07F5/025 ,  C07B2200/13

Abstract: The present invention relates to boron containing compounds of Formula (I)


X—Y—Z   Formula (I)

that inhibit phosphodiesterase 4 (PDE4). The invention also encompasses pharmaceutical compositions containing these compounds and methods for treating diseases, conditions, or disorders ameliorated by inhibition of PDE4.

公开(公告)号：US11559538B2

公开(公告)日：2023-01-24

申请号：US17082102

申请日：2020-10-28

Applicant: Pfizer Inc.

Inventor： Joseph Walter Strohbach ,  Tsutomu Akama ,  David Clive Blakemore ,  Robert Toms Jacobs ,  Peter Jones ,  David Christopher Limburg ,  Martins Sunday Oderinde ,  Matthew Alexander Perry ,  Jacob John Plattner ,  Rubben Federico Torella ,  Yasheen Zhou ,  Thean Yeow Yeoh

IPC: C07F5/02 ,  A61K31/69 ,  A61K31/519

Abstract: The present invention relates to boron containing compounds of Formula (IA): that inhibit phosphodiesterase 4 (PDE4). The invention also encompasses pharmaceutical compositions containing these compounds and methods for treating diseases, conditions, or disorders ameliorated by inhibition of PDE4.

公开(公告)号：US10946031B2

公开(公告)日：2021-03-16

申请号：US16593171

申请日：2019-10-04

Applicant: Pfizer Inc.

Inventor： Joseph Walter Strohbach ,  David Clive Blakemore ,  Peter Jones ,  Matthew Alexander Perry

IPC: C07F5/02 ,  A61K31/69 ,  A61K31/519

Abstract: The present invention relates to PDE4 inhibitor (R)-4-(5-(4-methoxy-3-propoxyphenyl)pyridin-3-yl)-1,2-oxaborolan-2-ol including the crystalline monohydrate thereof.