公开(公告)号：US11691973B2

公开(公告)日：2023-07-04

申请号：US18060864

申请日：2022-12-01

Applicant: Pfizer Inc.

Inventor： Shelley Allen ,  Patrick Michael Doerner Barbour ,  James Francis Blake ,  Sydney Taylor Blanche ,  Mark Laurence Boys ,  Wesley Dewitt Clark ,  Connor James Cowdrey ,  Joshua Ryan Dahlke ,  Alex Andrew Kellum ,  Ellen Margaret Knapp ,  David Austin Moreno ,  Jacob Matthew O'Leary ,  Li Ren ,  Faith Elizabeth Witkos ,  Jennifer Lynn Fulton

IPC: C07D471/04 ,  A61P35/00 ,  A61K31/4375 ,  A61K45/06

CPC classification number: C07D471/04 ,  A61K31/4375 ,  A61K45/06 ,  A61P35/00

Abstract: The invention relates to a compound of Formula I




or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof. The invention further relates to solid forms of 8-((2-fluoro-4-(methylthio)phenyl)amino)-2-(2-hydroxyethoxy)-7-methyl-3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-dione.