公开(公告)号：US20230174532A1

公开(公告)日：2023-06-08

申请号：US18162052

申请日：2023-01-31

申请人： Pfizer Inc.

发明人： Christopher Ryan BUTLER ,  Michelle Renee GARNSEY ,  Kevin Alexander OGILVIE ,  Jana POLIVKOVA ,  Matthew Forrest SAMMONS ,  Aaron Christopher SMITH ,  Qingyi Yang

IPC分类号： C07D471/20 ,  C07D519/00

CPC分类号： C07D471/20 ,  C07D519/00 ,  C07B2200/13

摘要： Described herein are methods of treating MC4R-related conditions, diseases, or disorders by administering compounds of Formula I:




or their pharmaceutically acceptable salts, wherein R1, R2, R3, X1, Y1, Y2, Y3, Y4 and Y5 are defined herein. Such conditions, diseases, or disorders include cachexia, anorexia, or anorexia nervosa.