公开(公告)号：US20230043985A1

公开(公告)日：2023-02-09

申请号：US17786695

申请日：2020-12-15

申请人： Pfizer Inc.

发明人： Meng LI ,  Kai-Hsin LIAO ,  Shinji YAMAZAKI

IPC分类号： A61K31/519 ,  A61K31/337 ,  A61K39/395 ,  A61K9/20 ,  A61P35/04 ,  A61P11/00

摘要： A method of treating cancers, including pancreatic cancer, endometrial cancer, non-small cell lung cancer (NSCLC), endometrial cancer, cervical cancer, bladder cancer, head and neck squamous cell carcinoma (HNSCC), urothelial carcinoma, esophageal cancer, and other cancers, the method comprising once-daily administration, to a patient in need thereof, of a therapeutically effective amount of (1S,2S,3S,5R)-3-((6-(difluoromethyl)-5-fluoro-1,2,3,4-tetrahydroiso quinolin-8-yl)oxy)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl) cyclopentane-1,2-diol having the structure: Formula I or a pharmaceutically acceptable salt thereof.