公开(公告)号：US12296012B2

公开(公告)日：2025-05-13

申请号：US16617487

申请日：2018-05-31

Applicant: Pfizer Inc.

Inventor： Barbra Johnson Sasu ,  Danielle Elizabeth Dettling ,  Cesar Adolfo Sommer ,  Yik Andy Yeung ,  Moustafa Marc Hamze

IPC: A61K45/06 ,  A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61P35/02 ,  C07K14/705 ,  C07K14/715 ,  C07K14/725 ,  C07K16/28

Abstract: Provided herein are antibodies that specifically bind to Fms-like tyrosine kinase 3 (FLT3), chimeric antigen receptors (CARs) that specifically bind to FLT3, and engineered immune cells expressing such CARs (e.g. FLT3-specific CAR-T cells). The invention also provides making such antibodies, CARs, and engineered immune cells. The invention also provides using such antibodies, CARs, and engineered immune cells, for example for the treatment of a condition associated with malignant cells expressing FLT3 (e.g., cancer).