公开(公告)号：US20240076382A1

公开(公告)日：2024-03-07

申请号：US18354934

申请日：2023-07-19

Applicant: Pfizer Inc. ,  Children's Medical Center Corporation

Inventor： Florian WINAU ,  Oleg V. KOVALENKO ,  Chew Shun CHANG ,  Di WU ,  Nicholas Andrew MARZE ,  Shian-Huey CHIANG

IPC: C07K16/28 ,  A61P17/00

CPC classification number: C07K16/2833 ,  A61P17/00 ,  A61K2039/505

Abstract: Antibodies, and antigen-binding fragments thereof, that specifically bind to Cluster of Differentiation 1a (CD1a) are provided. Embodiments include uses, and associated methods of using the antibodies, and antigen-binding fragments thereof.

公开(公告)号：US20230406951A1

公开(公告)日：2023-12-21

申请号：US18323629

申请日：2023-05-25

Applicant: Pfizer Inc.

Inventor： Todd Douglas ASHWORTH ,  Yue LIU ,  Nicholas Andrew MARZE ,  Virginie MCMANUS

IPC: C07K16/28 ,  A61P37/06

CPC classification number: C07K16/2878 ,  A61P37/06 ,  A61K2039/505

Abstract: The present disclosure provides antibodies that bind to TNFR2 as well as uses of the antibodies and associated methods. The disclosure also provides processes for making, preparing, and producing antibodies that bind to TNFR2. Antibodies of the disclosure are useful in one or more of diagnosis, prophylaxis, or treatment of disorders or conditions mediated by, or associated with, TNFR2 activity.

公开(公告)号：US20220112291A1

公开(公告)日：2022-04-14

申请号：US17450283

申请日：2021-10-07

Applicant: Pfizer Inc. ,  Children's Medical Center Corporation

Inventor： Florian WINAU ,  Oleg V. KOVALENKO ,  Chew Shun CHANG ,  Di WU ,  Nicholas Andrew MARZE ,  Shian-Huey CHIANG

IPC: C07K16/28 ,  A61P17/00

Abstract: Antibodies, and antigen-binding fragments thereof, that specifically bind to Cluster of Differentiation 1a (CD1a) are provided. Embodiments include uses, and associated methods of using the antibodies, and antigen-binding fragments thereof.

公开(公告)号：US20240052047A1

公开(公告)日：2024-02-15

申请号：US18363152

申请日：2023-08-01

Applicant: Pfizer Inc.

Inventor： Yijie GAO ,  Nicholas Andrew MARZE ,  Laird BLOOM

IPC: C07K16/28

CPC classification number: C07K16/2866 ,  C07K16/2803 ,  A61K2039/505

Abstract: The present invention relates to antibodies that specifically bind to one or both of IL27RA and gp130. The present invention further relates to bispecific antibodies that specifically bind to IL27RA and gp130. The present invention also pertains to related molecules, e.g. nucleic acids which encode such antibodies or bispecific antibodies, compositions, and related methods, e.g., methods for producing and purifying such antibodies and bispecific antibodies, and their use in diagnostics and therapeutics