公开(公告)号：US20230405002A1

公开(公告)日：2023-12-21

申请号：US17904554

申请日：2021-02-22

Applicant: Pfizer Inc.

Inventor： Neeta Balkrishan Amin ,  Arthur James Bergman ,  Roberto Arnaldo Calle ,  Robert Gregory Dullea ,  David James Edmonds ,  William Paul Esler ,  Kevin James Filipski ,  James Richard Gosset ,  Albert Myung Kim ,  Jeffrey Allen Pfefferkorn ,  Patrick Robert Verhoest

IPC: A61K31/506 ,  A61K31/4545 ,  A61P1/16 ,  A61P3/04

CPC classification number: A61K31/506 ,  A61K31/4545 ,  A61P1/16 ,  A61P3/04

Abstract: Described herein are pharmaceutical compositions comprising 2-{5-[(3-ethoxypyridin-2-yl)oxy]pyridin-3-yl}-N-[(3S,5S)-5-fluoropiperidin-3-yl]pyrimidine-5-carboxamide, or pharmaceutically acceptable salt thereof, for treatment of liver disease and diseases related thereto. Also described are compositions comprising 2-{5-[(3-ethoxypyridin-2-yl)oxy]pyridin-3-yl}-N-[(3S,5S)-5-fluoropiperidin-3-yl]pyrimidine-5-carboxamide, or pharmaceutically acceptable salt thereof and 4-(4-(1-Isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4′-piperidine]-1′-carbonyl)-6-methoxypyridin-2-yl)benzoic acid, or pharmaceutically acceptable salt thereof, for treatment of liver disease and diseases related thereto.