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1.发明授权公开(公告)号：US10023649B2
公开(公告)日：2018-07-17
申请号：US15312515
申请日：2015-05-15
Applicant: Pfizer Inc. , KYOWA HAKKO KIRIN CO., LTD.
Inventor： Chia-Yang Lin , Shihao Chen , LiFen Lee , Shobha Potluri , Denis Healy , Margaret Marshall , Naoki Sawada
Abstract: The present disclosure describes combination therapies comprising an antibody which specifically binds to human CCR4 and a selective 4-1BB agonist, and the use of the combination therapies for the treatment of cancer.
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公开(公告)号：US20230250173A1
公开(公告)日：2023-08-10
申请号：US18002942
申请日：2021-06-29
Applicant: Pfizer Inc.
Inventor： Keith Anthony Ching , Craig Davis , Xinmeng Mu , Shobha Potluri , Yan Qu , Shahram Salek-Ardakani , Graham Thomas , Ji Wen
IPC: C07K16/28 , C12Q1/6886 , A61P35/00 , A61P13/02
CPC classification number: C07K16/2818 , C12Q1/6886 , A61P35/00 , A61P13/02 , C12Q2600/106 , C12Q2600/158
Abstract: The present disclosure describes therapies comprising a PD-1 axis binding antagonist, wherein a sample from the patient has been pre-determined to have certain biomarkers.
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公开(公告)号：US20170088627A1
公开(公告)日：2017-03-30
申请号：US15312515
申请日：2015-05-15
Applicant: Pfizer Inc. , KYOWA HAKKO KIRIN CO., LTD.
Inventor： Chia-Yang Lin , Shihao Chen , LiFen Lee , Shobha Potluri , Denis Healy , Margaret Marshall , Naoki Sawada
IPC: C07K16/30 , A61K47/12 , A61K47/26 , A61K39/395 , A61K47/18
CPC classification number: C07K16/30 , A61K39/39558 , A61K47/12 , A61K47/183 , A61K47/26 , A61K2039/505 , A61K2039/545 , C07K16/2866 , C07K16/2878 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K16/3046 , C07K16/3053 , C07K16/3069 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/75
Abstract: The present disclosure describes combination therapies comprising an antibody which specifically binds to human CCR4 and a selective 4-1BB agonist, and the use of the combination therapies for the treatment of cancer.
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