公开(公告)号：US08846037B2

公开(公告)日：2014-09-30

申请号：US13857867

申请日：2013-04-05

Applicant: Pfizer Inc. ,  Bristol-Myers Squibb Company

Inventor： Arvind Rajpal ,  Madhav Narasimha Devalaraja ,  Kristopher Toy ,  Lan Yang ,  Haichun Huang ,  Jun Zhang ,  Peter Brams ,  Brigitte Devaux ,  David B. Passmore

IPC: A61K39/395 ,  A61K39/00 ,  C07K16/24

CPC classification number: C07K16/248 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/92

Abstract: Antibodies and antigen-binding portions thereof that bind to human IL-6 are provided. Also provided are nucleic acids encoding such antibodies and antigen binding portions, methods of making such antibodies and antigen binding portions, compositions comprising such antibodies or antigen binding portions, and uses of such antibodies or antigen binding portions.

Abstract translation: 提供了结合人IL-6的抗体及其抗原结合部分。 还提供了编码此类抗体和抗原结合部分的核酸，制备此类抗体和抗原结合部分的方法，包含此类抗体或抗原结合部分的组合物，以及此类抗体或抗原结合部分的用途。

公开(公告)号：US20150203574A1

公开(公告)日：2015-07-23

申请号：US14473997

申请日：2014-08-29

Applicant: Pfizer Inc. ,  BRISTOL-MYERS SQUIBB COMPANY

Inventor： Arvind Rajpal ,  Madhav Narasimha Devalaraja ,  Kristopher Toy ,  Lan Yang ,  Haichun Huang ,  Jun Zhang ,  Peter Brams ,  Brigitte Devaux ,  David B. Passmore

IPC: C07K16/24

CPC classification number: C07K16/248 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/92

Abstract: Antibodies and antigen-binding portions thereof that bind to human IL-6 are provided. Also provided are nucleic acids encoding such antibodies and antigen binding portions, methods of making such antibodies and antigen binding portions, compositions comprising such antibodies or antigen binding portions, and uses of such antibodies or antigen binding portions.