公开(公告)号：US09987341B2

公开(公告)日：2018-06-05

申请号：US15266812

申请日：2016-09-15

申请人： Pfizer Vaccines LLC

发明人： Brian Robert Champion, Jr. ,  Leonard Gabriel Contillo, Jr. ,  Michael Dale Eisenbraun ,  James Downey Fraser ,  Julie Jia Li Hawkins ,  James Richard Merson ,  Brian Gregory Pierce ,  Xiayang Qiu ,  Jakir Hussain Ullah ,  David Michael Wyatt

IPC分类号： A61K39/00

CPC分类号： A61K39/0005 ,  C12N9/6424 ,  C12Y304/21061

摘要： The present invention relates to the provision of novel immunogens comprising an antigenic PCSK9 peptide linked to an immunogenic carrier for the prevention, treatment or alleviation of PCSK9-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.

公开(公告)号：US20180318407A1

公开(公告)日：2018-11-08

申请号：US15957835

申请日：2018-04-19

申请人： Pfizer Vaccines LLC

发明人： Brian Robert Champion ,  Leonard Gabriel Contillo, Jr. ,  Michael Dale Eisenbraun ,  James Downey Fraser ,  Julie Jia Li Hawkins ,  James Richard Merson ,  Brian Gregory Pierce ,  Xiayang Qiu ,  Jakir Hussain Ullah ,  David Michael Wyatt

IPC分类号： A61K39/00 ,  C12N9/64

CPC分类号： A61K39/0005 ,  C12N9/6424 ,  C12Y304/21061

摘要： The present invention relates to the provision of novel immunogens comprising an antigenic PCSK9 peptide linked to an immunogenic carrier for the prevention, treatment or alleviation of PCSK9-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.

公开(公告)号：US20170100467A1

公开(公告)日：2017-04-13

申请号：US15266812

申请日：2016-09-15

申请人： Pfizer Vaccines LLC

发明人： Brian Robert Champion ,  Leonard Gabriel Contillo, JR. ,  Michael Dale Eisenbraun ,  James Downey Fraser ,  Julie Jia Li Hawkins ,  James Richard Merson ,  Brian Gregory Pierce ,  Xiayang Qiu ,  Jakir Hussain Ullah ,  David Michael Wyatt

IPC分类号： A61K39/00

CPC分类号： A61K39/0005 ,  C12N9/6424 ,  C12Y304/21061

摘要： The present invention relates to the provision of novel immunogens comprising an antigenic PCSK9 peptide linked to an immunogenic carrier for the prevention, treatment or alleviation of PCSK9-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.