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    Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
    1.
    发明申请
    Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents 审中-公开
    丙烯酰取代的雷霉霉素衍生物，其制备方法及其作为抗肿瘤剂和抗病毒剂的用途

    公开(公告)号：US20030023031A1

    公开(公告)日：2003-01-30

    申请号：US10196363

    申请日：2002-07-17

    申请人： Pharmacia & Upjohn S.p.A.

    发明人： Paolo Cozzi ,  Italo Beria ,  Giovanni Biasoli ,  Marina Caldarelli ,  Laura Capolongo ,  Cristina Franzetti

    IPC分类号： C07K005/06 ,  C07K005/08 ,  C07K005/10 ,  C07D43/02

    CPC分类号： C07D207/34

    摘要： According to the invention, there is provided a method of manufacturing a medicament for use in the treatment of cancer or viral infections which comprises obtaining a cancer treating effective amount of a compound of formula (I), 1 and combining the compound of formula (I) with at least one pharmaceutically acceptable excipient, and wherein the cancer treating effective amount of a compound of formula I is an acryloyl substituted distamycin derivative in which n, R1 and R2, R3, B, are defined herein or a pharmaceutically acceptable salt thereof to produce a medicament for use in the treatment of cancer or viral infections.

    摘要翻译： 根据本发明，提供了一种制备用于治疗癌症或病毒感染的药物的方法，其包括获得癌症治疗有效量的式（I）化合物，并将式（I）化合物 与至少一种药学上可接受的赋形剂，并且其中治疗有效量的式I化合物的癌症是其中n，R1和R2，R3，B在本文中定义的丙烯酰取代的空白霉素衍生物或其药学上可接受的盐以产生 用于治疗癌症或病毒感染的药物。