公开(公告)号：US5773003A

公开(公告)日：1998-06-30

申请号：US456444

申请日：1995-06-01

申请人： Philip A. Swain ,  Victoria Carol Schad ,  Julia Lea Greenstein ,  Mark Adrian Exley ,  Barbara Saxton Fox ,  Stephen P. Powers ,  Malcolm L. Gefter

发明人： Philip A. Swain ,  Victoria Carol Schad ,  Julia Lea Greenstein ,  Mark Adrian Exley ,  Barbara Saxton Fox ,  Stephen P. Powers ,  Malcolm L. Gefter

IPC分类号： A61K47/48 ,  A61P25/30 ,  A61K39/385 ,  A61K39/12

CPC分类号： C07K16/44 ,  A61K39/0013 ,  A61K47/4833 ,  A61K2039/6037

摘要： Hapten-carrier conjugates capable of eliciting anti hapten antibodies in vivo by administering, in a therapeutic composition, are disclosed. Anti-hapten antibodies elicited compete with free hapten upon subsequent challenge of a vaccinated individual. Methods of preparing the conjugates and therapeutic compositions are also disclosed. Where the hapten is a drug of abuse, a therapeutic composition containing the hapten-carrier conjugate is particularly useful in the treatment of drug addiction, more particularly, cocaine addiction. Passive immunization using antibodies raised against conjugates of the instant invention is also disclosed. The therapeutic composition is suitable for co-therapy with other conventional drugs.

摘要翻译： 公开了通过在治疗组合物中施用能够在体内引发抗半抗原抗体的穿孔载体缀合物。 抗半抗原抗体引起与免疫半抗原的竞争，随后对接种疫苗的个体进行攻击。 还公开了制备缀合物和治疗组合物的方法。 当半抗原是滥用药物时，含有半抗原 - 载体结合物的治疗组合物特别可用于治疗药物成瘾，特别是可卡因成瘾。 还公开了使用针对本发明的缀合物产生的抗体的被动免疫。 该治疗组合物适用于与其它常规药物共同治疗。

公开(公告)号：US5840307A

公开(公告)日：1998-11-24

申请号：US457206

申请日：1995-06-01

申请人： Philip A. Swain ,  Victoria Carol Schad ,  Julia Lea Greenstein ,  Mark Adrian Exley ,  Barbara Saxton Fox ,  Stephen P. Powers ,  Malcolm L. Gefter

发明人： Philip A. Swain ,  Victoria Carol Schad ,  Julia Lea Greenstein ,  Mark Adrian Exley ,  Barbara Saxton Fox ,  Stephen P. Powers ,  Malcolm L. Gefter

IPC分类号： A61K47/48 ,  A61P25/30 ,  A61K39/385 ,  A61K39/00 ,  A61K39/395 ,  C07P451/02

CPC分类号： C07K16/44 ,  A61K39/0013 ,  A61K47/4833 ,  A61K2039/6037

摘要： Hapten-carrier conjugates capable of eliciting anti hapten antibodies in vivo by administering, in a therapeutic composition, are disclosed. Anti-hapten antibodies elicited compete with free hapten upon subsequent challenge of a vaccinated individual. Methods of preparing said conjugates and therapeutic compositions are also disclosed. Where the hapten is a drug of abuse, a therapeutic composition containing the hapten-carrier conjugate is particularly useful in the treatment of drug addiction, more particularly, cocaine addiction. Passive immunization using antibodies raised against conjugates of the instant invention is also disclosed. The therapeutic composition is suitable for co-therapy with other conventional drugs.

摘要翻译： 公开了通过在治疗组合物中施用能够在体内引发抗半抗原抗体的穿孔载体缀合物。 抗半抗原抗体引起与免疫半抗原的竞争，随后对接种疫苗的个体进行攻击。 还公开了制备所述缀合物和治疗组合物的方法。 当半抗原是滥用药物时，含有半抗原 - 载体结合物的治疗组合物特别可用于治疗药物成瘾，特别是可卡因成瘾。 还公开了使用针对本发明的缀合物产生的抗体的被动免疫。 该治疗组合物适用于与其它常规药物共同治疗。