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公开(公告)号：US08895570B2
公开(公告)日：2014-11-25
申请号：US13994321
申请日：2011-12-14
申请人： Phillip Abbott , Roger Victor Bonnert , Thomas McInally , Stephen Thom , Hiroki Wada , Satoshi Onuma
发明人： Phillip Abbott , Roger Victor Bonnert , Thomas McInally , Stephen Thom , Hiroki Wada , Satoshi Onuma
IPC分类号： A61K31/52 , C07D473/18
CPC分类号： C07D473/18
摘要： The invention provides the compound of formula (I) and pharmaceutically acceptable salt thereof, pharmaceutical compositions containing the compound and the use of the compound in therapy.
摘要翻译： 本发明提供式（I）化合物及其药学上可接受的盐，其含有该化合物的药物组合物和该化合物在治疗中的用途。
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公开(公告)号：US20130338174A1
公开(公告)日：2013-12-19
申请号：US13994321
申请日：2011-12-14
申请人： Phillip Abbott , Roger Victor Bonnert , Thomas Mcinally , Stephen Thom , Hiroki Wada , Satoshi Onuma
发明人： Phillip Abbott , Roger Victor Bonnert , Thomas Mcinally , Stephen Thom , Hiroki Wada , Satoshi Onuma
IPC分类号： C07D473/18
CPC分类号： C07D473/18
摘要： The invention provides the compound of formula (I) and pharmaceutically acceptable salt thereof, pharmaceutical compositions containing the compound and the use of the compound in therapy.
摘要翻译： 本发明提供式（I）化合物及其药学上可接受的盐，其含有该化合物的药物组合物和该化合物在治疗中的用途。
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公开(公告)号：US08436178B2
公开(公告)日：2013-05-07
申请号：US12596817
申请日：2008-05-06
IPC分类号： C07D471/02
CPC分类号： C07D471/04
摘要： The present invention provides compounds of formula (I) wherein Ra, R1, R2, R3, X1, Y1, Z1, A, n and m are as defined in the specification, and pharmaceutically acceptable salts thereof, as well as processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译： 本发明提供了其中Ra，R1，R2，R3，X1，Y1，Z1，A，n和m如说明书中所定义的式（I）化合物及其药学上可接受的盐，以及其制备方法 ，含有它们的药物组合物及其在治疗中的用途。
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公开(公告)号：US20100280001A1
公开(公告)日：2010-11-04
申请号：US12596817
申请日：2008-05-06
IPC分类号： A61K31/437 , C07D471/04 , A61K31/496 , A61K31/5377 , A61P31/00 , A61P35/00 , A61P31/14 , A61P31/12 , A61P17/00 , A61P11/06 , A61P11/00
CPC分类号： C07D471/04
摘要： The present invention provides compounds of formula (I) wherein Ra, R1, R2, R3, X1, Y1, Z1, A, n and m are as defined in the specification, and pharmaceutically acceptable salts thereof, as well as processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译： 本发明提供了其中Ra，R1，R2，R3，X1，Y1，Z1，A，n和m如说明书中所定义的式（I）化合物及其药学上可接受的盐，以及其制备方法 ，含有它们的药物组合物及其在治疗中的用途。
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5.发明申请9-SUBSTITUTED-8-OXO-ADENINE COMPOUNDS AS TOLL-LIKE RECEPTOR (TLR7) MODULATORS 失效作为类似感受器（TLR7）调节剂的9-替代的8-氧 - 腺嘌呤化合物公开(公告)号：US20100087443A1
公开(公告)日：2010-04-08
申请号：US12532084
申请日：2008-03-19
IPC分类号： A61K31/522 , C07D473/18 , A61K31/496 , A61P11/00 , A61P35/00 , A61P31/00
CPC分类号： C07D473/18
摘要： The present invention provides compounds of formula where n, R1, R2, A, X1, Y1, Z1, X2 and Y2 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译： 本发明提供下式的化合物，其中n，R1，R2，A，X1，Y1，Z1，X2和Y2如说明书中所定义，其制备方法，含有它们的药物组合物及其在治疗中的用途。
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6.发明申请PURINE DERIVATIVES FOR THE TREATMENT OF VIRAL OR ALLERGIC DISEASES AND CANCERS 审中-公开用于治疗病毒或过敏性疾病和癌症的嘌呤衍生物公开(公告)号：US20090082332A1
公开(公告)日：2009-03-26
申请号：US12067536
申请日：2006-09-20
申请人： Philip Abbot , Roger Victor Bonnert , Stephen Brough , Kamaldeep Chohan , Thomas McInally , Stephen Thom , Yoshiaki Isobe , Kei Nakamura , Shingo Tojo
发明人： Philip Abbot , Roger Victor Bonnert , Stephen Brough , Kamaldeep Chohan , Thomas McInally , Stephen Thom , Yoshiaki Isobe , Kei Nakamura , Shingo Tojo
IPC分类号： A61K31/397 , C07D473/02 , A61P31/12 , A61P35/00 , A61P37/08 , A61K31/522
CPC分类号： C07D473/34
摘要： The present invention provides compounds of formula (I) wherein R1, Y1, X1, Z1, X2, Y2, A, Y3, n, R and R2 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译： 本发明提供式（I）化合物，其中R1，Y1，X1，Z1，X2，Y2，A，Y3，n，R和R2如说明书中所定义，其制备方法，含有它们的药物组合物及其制备方法 用于治疗。
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7.发明授权9-substituted-8-oxo-adenine compounds as toll-like receptor (TLR7 ) modulators 有权9-取代-8-氧代腺嘌呤化合物作为片段受体（TLR7）调节剂公开(公告)号：US08067413B2
公开(公告)日：2011-11-29
申请号：US12532090
申请日：2008-03-19
IPC分类号： C07D473/18 , A61K31/522 , A61P11/06 , A61P37/08
CPC分类号： C07D473/18
摘要： The present invention provides compounds of formula (I) wherein R1, Y1, X1, L and R2 are as defined in the specification, and pharmaceutically acceptable salts thereof, as well as processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译： 本发明提供其中R1，Y1，X1，L和R2如说明书中所定义的式（I）化合物及其药学上可接受的盐，以及其制备方法，含有它们的药物组合物及其在治疗中的用途 。
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公开(公告)号：US08067411B2
公开(公告)日：2011-11-29
申请号：US11955984
申请日：2007-12-13
IPC分类号： C07D473/18 , A61K31/522 , A61P11/06 , A61P37/08
CPC分类号： C07D473/18
摘要： The present invention provides compounds of formula wherein R1, Y1, X1, Z1, X2, Y2, A, n and R2 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译： 本发明提供下式的化合物，其中R1，Y1，X1，Z1，X2，Y2，A，n和R2如说明书中所定义，其制备方法，含有它们的药物组合物及其在治疗中的用途。
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9.发明授权9-substituted-8-oxo-adenine compounds as toll-like receptor (TLR7) modulators 失效9-取代-8-氧代腺嘌呤化合物作为片段受体（TLR7）调节剂公开(公告)号：US08063051B2
公开(公告)日：2011-11-22
申请号：US12532084
申请日：2008-03-19
IPC分类号： C07D473/18 , A61K31/522 , A61P37/08 , A61P11/06
CPC分类号： C07D473/18
摘要： The present invention provides compounds of formula where n, R1, R2, A, X1, Y1, Z1, X2 and Y2 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译： 本发明提供下式的化合物，其中n，R1，R2，A，X1，Y1，Z1，X2和Y2如说明书中所定义，其制备方法，含有它们的药物组合物及其在治疗中的用途。
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10.发明申请9-SUBSTITUTED-8-OXO-ADENINE COMPOUNDS AS TOLL-LIKE RECEPTOR (TLR7 ) MODULATORS 有权作为类似感受器（TLR7）调节剂的9-替代的8-氧 - 腺嘌呤化合物公开(公告)号：US20100130491A1
公开(公告)日：2010-05-27
申请号：US12532090
申请日：2008-03-19
IPC分类号： A61K31/522 , C07D473/18 , A61K31/5377 , A61P35/00 , A61P37/08 , A61P31/12 , A61P31/18 , A61P31/04 , A61P11/06 , A61P1/16 , A61P17/00 , A61P11/02 , A61P11/00
CPC分类号： C07D473/18
摘要： The present invention provides compounds of formula (I) wherein R1, Y1, X1, L and R2 are as defined in the specification, and pharmaceutically acceptable salts thereof, as well as processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译： 本发明提供其中R1，Y1，X1，L和R2如说明书中所定义的式（I）化合物及其药学上可接受的盐，以及其制备方法，含有它们的药物组合物及其在治疗中的用途 。
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