公开(公告)号：US06406421B1

公开(公告)日：2002-06-18

申请号：US09149021

申请日：1998-09-08

申请人： Pierre Andre Grandjean ,  David E. Francischelli ,  Kendra K. Gealow ,  Robert Leinders ,  Martinus A. G. M. Bakx ,  Koen J. Weijand

发明人： Pierre Andre Grandjean ,  David E. Francischelli ,  Kendra K. Gealow ,  Robert Leinders ,  Martinus A. G. M. Bakx ,  Koen J. Weijand

IPC分类号： A61M112

CPC分类号： A61N1/36042 ,  A61B5/053 ,  A61B5/1107 ,  A61B5/4519 ,  A61B5/6869 ,  A61M1/1003 ,  A61M1/1068 ,  A61M1/1086 ,  A61M1/12 ,  A61M1/127 ,  A61M2205/33 ,  A61M2205/3303

摘要： There is provided a system and method for continually monitoring the occurrence of contraction during stimulation of skeletal muscle which is employed in a cardiac assist-type system. During delivery of a periodic burst, or train of stimulus pulses, the impedance of the muscle between the electrodes through which the pulses are delivered is monitored, and evaluated to determine whether or not stimulation has been achieved. In a particular embodiment, the impedance and impedance derivative values are accumulated throughout the burst, and assessed to determine whether the impedance change corresponded to a full muscle contraction. In the event of failure to stimulate the muscle to contraction, the system can automatically adjust the pulse output parameters to achieve reliable contraction.

摘要翻译： 提供了用于在心脏辅助型系统中使用的骨骼肌刺激期间持续监测收缩发生的系统和方法。 在递送周期性突发或刺激脉冲序列期间，监测通过其传送脉冲的电极之间的肌肉的阻抗，并进行评估以确定是否已经实现刺激。 在特定实施例中，阻抗和阻抗导数值在整个突发期间被累积，并被评估以确定阻抗变化是否对应于完全肌肉收缩。 在无法刺激肌肉收缩的情况下，系统可以自动调节脉搏输出参数，达到可靠的收缩。

公开(公告)号：US5716391A

公开(公告)日：1998-02-10

申请号：US526055

申请日：1995-08-23

申请人： Pierre Andre Grandjean

发明人： Pierre Andre Grandjean

IPC分类号： A61N1/05

CPC分类号： A61N1/0573 ,  A61N1/05

摘要： A medical electrical lead having active fixation which readily flexes within the cardiac tissue through a fixation mechanism which is temporarily rigid. In a preferred embodiment, the medical electrical lead features a fixation helix constructed from an absorbable material, such as mannitol. In an alternate embodiment a medical electrical lead is disclosed which features a fixation mechanism having a multi-layer construction. In that embodiment the fixation mechanism is fashioned of a first, rigid and absorbable, material and a second, readily pliable and nonabsorbable, material. Through such a construction the lead may be fixed in the tissue such that over time the first material is absorbed by the body and the second material is left in position to flexibly fix the lead in place. In one embodiment the second material is conductive and is used to achieve an electrical coupling to the body tissue.

摘要翻译： 一种具有主动固定的医用电线，其通过临时刚性的固定机构容易地在心脏组织内弯曲。 在优选实施例中，医用电引线具有由可吸收材料（例如甘露醇）构成的固定螺旋。 在替代实施例中，公开了一种具有多层结构的固定机构的医用电线。 在该实施例中，固定机构由第一，刚性和可吸收的材料和第二容易柔软和不可吸收的材料制成。 通过这样的结构，引线可以固定在组织中，使得随着时间的推移，第一材料被主体吸收，并且第二材料被放置在适当的位置以将引线柔性地固定就位。 在一个实施例中，第二材料是导电的并且用于实现与身体组织的电耦合。