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公开(公告)号：US07977342B2
公开(公告)日：2011-07-12
申请号：US11684288
申请日：2007-03-09
申请人： Kenneth Alan Simmen , Tse-I Lin , Oliver Lenz , Dominique Louis Nestor Ghislain Surleraux , Pierre Jean-Marie Bernard Raboisson
发明人： Kenneth Alan Simmen , Tse-I Lin , Oliver Lenz , Dominique Louis Nestor Ghislain Surleraux , Pierre Jean-Marie Bernard Raboisson
IPC分类号： A01N43/54 , A01N43/90 , A61K31/517 , A61K31/519
CPC分类号： A61K31/517 , A61K31/519 , A61K31/52 , A61K31/53 , A61K31/5377 , Y02A50/385 , Y02A50/387
摘要： The present invention relates to the use of bi-cyclic pyrimidines as inhibitors of HCV replication as well as their use in pharmaceutical compositions aimed to treat or combat HCV infections. In addition, the present invention relates to processes for preparation of such pharmaceutical compositions. The present invention also concerns combinations of the present bi-cyclic pyrimidines with other anti-HCV agents.
摘要翻译： 本发明涉及双环嘧啶作为HCV复制抑制剂的用途，以及它们在旨在治疗或对抗HCV感染的药物组合物中的用途。 此外，本发明涉及这种药物组合物的制备方法。 本发明还涉及本发明的双环嘧啶与其它抗HCV药物的组合。
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![PYRIDO[2,3-D]PYRIMIDINES USEFUL AS HCV INHIBITORS, AND METHODS FOR THE PREPARATION THEREOF](/abs-image/US/2009/05/21/US20090131460A1/abs.jpg.150x150.jpg)
2.发明申请PYRIDO[2,3-D]PYRIMIDINES USEFUL AS HCV INHIBITORS, AND METHODS FOR THE PREPARATION THEREOF 有权用作HCV抑制剂的吡咯并[2,3-D]吡咯烷酮及其制备方法公开(公告)号：US20090131460A1
公开(公告)日：2009-05-21
申请号：US11914044
申请日：2006-05-12
申请人： Kenneth Alan Simmen , Dominique Louis Nestor Ghislain Surleraux , Tse-I Lin , Oliver Lenz , Pierre Jean-Marie Bernard Raboisson
发明人： Kenneth Alan Simmen , Dominique Louis Nestor Ghislain Surleraux , Tse-I Lin , Oliver Lenz , Pierre Jean-Marie Bernard Raboisson
IPC分类号： A61K31/519 , C07D401/14 , A61P31/14
CPC分类号： C07D471/04 , A61K31/519
摘要： The present invention relates to the use of pyrido[2,3-d]pyrimidines as inhibitors of HCV replication as well as their use in pharmaceutical compositions aimed to treat or combat HCV infections. In addition, the present invention relates to pyrido-[2,3-d]pyrimidines compounds per se and their use as medicines. The present invention also concerns processes for the preparation of such compounds, pharmaceutical compositions comprising them, and combinations of said compounds with other anti-HCV agents.
摘要翻译： 本发明涉及吡啶并[2,3-d]嘧啶作为HCV复制的抑制剂的用途，以及它们在旨在治疗或对抗HCV感染的药物组合物中的用途。 此外，本发明涉及吡啶并[2,3-d]嘧啶化合物本身及其作为药物的用途。 本发明还涉及制备这些化合物的方法，包含它们的药物组合物以及所述化合物与其它抗HCV药剂的组合。
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公开(公告)号：US20080182863A1
公开(公告)日：2008-07-31
申请号：US11909118
申请日：2006-03-27
申请人： Kenneth Alan Simmen , Dominique Louis Nestor Ghislain Surleraux , Tse-I Lin , Oliver Lenz , Pierre Jean-Marie Bernard Raboisson , Sarvajit Chakravarty , Barry Patrick Hart
发明人： Kenneth Alan Simmen , Dominique Louis Nestor Ghislain Surleraux , Tse-I Lin , Oliver Lenz , Pierre Jean-Marie Bernard Raboisson , Sarvajit Chakravarty , Barry Patrick Hart
IPC分类号： A61K31/519 , C07D471/04 , A61P31/14
CPC分类号： C07D471/04 , A61K31/495
摘要： Certain appropriately substituted fused bicyclic pyrimidine compounds having an amide-substituted pyridylamine group at C-4 of the pyrimidine ring are useful in the treatment of conditions associated with HCV.
摘要翻译： 在嘧啶环的C-4处具有酰胺取代的吡啶基胺基团的某些适当取代的稠合双环嘧啶化合物可用于治疗与HCV相关的病症。
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4.发明申请Pteridines useful as HCV inhibitors and methods for the preparation thereof 审中-公开可用作HCV抑制剂的蝶啶类及其制备方法公开(公告)号：US20090156595A1
公开(公告)日：2009-06-18
申请号：US11914018
申请日：2006-05-12
申请人： Pierre Jean-Marie Bernard Raboisson , Dominique Louis Nestor Ghislain Surleraux , Tse-I Lin , Oliver Lenz , Kenneth Alan Simmen
发明人： Pierre Jean-Marie Bernard Raboisson , Dominique Louis Nestor Ghislain Surleraux , Tse-I Lin , Oliver Lenz , Kenneth Alan Simmen
IPC分类号： A61K31/5377 , A61K31/4985 , C07D475/00 , C07D413/14 , A61P31/12
CPC分类号： C07D475/10 , A61K31/519 , A61K31/5377 , A61K45/06 , C07D487/04 , Y02A50/385 , Y02A50/387 , A61K2300/00
摘要： The present invention relates to the use of pteridines as inhibitors of HCV replication as well as their use in pharmaceutical compositions aimed to treat or combat HCV infections. In addition, the present invention relates to compounds per se and their use as medicines. The present invention also concerns processes for the preparation of such compounds, pharmaceutical compositions comprising them, and combinations of said compounds with other anti-HCV agents.
摘要翻译： 本发明涉及使用蝶啶作为HCV复制的抑制剂，以及它们在旨在治疗或对抗HCV感染的药物组合物中的用途。 此外，本发明涉及化合物本身及其作为药物的用途。 本发明还涉及制备这些化合物的方法，包含它们的药物组合物以及所述化合物与其它抗HCV药剂的组合。
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![Pyrido[2,3-d]pyrimidines useful as HCV inhibitors, and methods for the preparation thereof](/abs-image/US/2011/09/20/US08022077B2/abs.jpg.150x150.jpg)
5.发明授权Pyrido[2,3-d]pyrimidines useful as HCV inhibitors, and methods for the preparation thereof 有权可用作HCV抑制剂的吡啶并[2,3-d]嘧啶及其制备方法公开(公告)号：US08022077B2
公开(公告)日：2011-09-20
申请号：US11914044
申请日：2006-05-12
申请人： Kenneth Alan Simmen , Dominique Louis Nestor Ghislain Surleraux , Tse-I Lin , Oliver Lenz , Pierre Jean-Marie Bernard Raboisson
发明人： Kenneth Alan Simmen , Dominique Louis Nestor Ghislain Surleraux , Tse-I Lin , Oliver Lenz , Pierre Jean-Marie Bernard Raboisson
IPC分类号： C07D471/04 , A61K31/519 , A61P1/16 , A61P31/12
CPC分类号： C07D471/04 , A61K31/519
摘要： The present invention relates to the use of pyrido[2,3-d]pyrimidines of formula (I) wherein L, R1, R2 and R3 have specific meaning. The present invention also relates to the use of the compounds of formula (I) as inhibitors of HCV replication as well as their use in pharmaceutical compositions aimed to treat or combat HCV infections. In addition, the present invention relates to compounds of formula (I) per se and their use as medicines. The present invention also concerns processes for the preparation of such compounds, pharmaceutical compositions comprising them, and combinations of said compounds with other anti-HCV agents.
摘要翻译： 本发明涉及式（I）的吡啶并[2,3-d]嘧啶，其中L，R 1，R 2和R 3具有特定含义。 本发明还涉及式（I）化合物作为HCV复制的抑制剂的用途，以及它们在旨在治疗或对抗HCV感染的药物组合物中的用途。 此外，本发明涉及式（I）化合物本身及其作为药物的用途。 本发明还涉及制备这些化合物的方法，包含它们的药物组合物以及所述化合物与其它抗HCV药剂的组合。
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公开(公告)号：US08030318B2
公开(公告)日：2011-10-04
申请号：US11909118
申请日：2006-03-27
申请人： Kenneth Alan Simmen , Dominique Louis Nestor Ghislain Surleraux , Tse-I Lin , Oliver Lenz , Pierre Jean-Marie Bernard Raboisson , Sarvajit Chakravarty , Barry Patrick Hart
发明人： Kenneth Alan Simmen , Dominique Louis Nestor Ghislain Surleraux , Tse-I Lin , Oliver Lenz , Pierre Jean-Marie Bernard Raboisson , Sarvajit Chakravarty , Barry Patrick Hart
IPC分类号： A61K31/519 , C07D471/04
CPC分类号： C07D471/04 , A61K31/495
摘要： Substituted fused bicyclic pyrimidine compounds having an amide-substituted pyridylamine group at C-4 of the pyrimidine ring are useful in the treatment of conditions associated with HCV.
摘要翻译： 在嘧啶环的C-4处具有酰胺取代的吡啶基胺基的取代的稠合双环嘧啶化合物可用于治疗与HCV相关的病症。
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![Carboxamide 4-[(4-pyridyl)amino] pryimidines for the treatment of hepatitis C](/abs-image/US/2018/06/05/US09987277B2/abs.jpg.150x150.jpg)
公开(公告)号：US09987277B2
公开(公告)日：2018-06-05
申请号：US12443190
申请日：2007-10-04
IPC分类号： A61K31/21 , A61K31/506 , A61K31/535
CPC分类号： A61K31/506 , A61K31/535 , A61K2300/00
摘要： The present invention relates to the use of carboxamide 4-[(4-pyridyl)amino]-pyrimidines as inhibitors of HCV replication as well as their use in pharmaceutical compositions aimed to treat or combat HCV infections.
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8.发明申请Combination of a Macrocyclic Inhibitor of HCV, A Non-Nucleoside and a Nucleoside 审中-公开HCV，非核苷和核苷的大环抑制剂的组合公开(公告)号：US20130028865A1
公开(公告)日：2013-01-31
申请号：US13640657
申请日：2011-04-13
CPC分类号： A61K31/4709 , A61K31/427 , A61K31/506 , A61K31/55 , A61K2300/00
摘要： The present invention relates to a combination of a macrocyclic HCV protease inhibitor, a macrocyclic non-nucleoside HCV polymerase inhibitor and a nucleoside HCV polymerase inhibitor.
摘要翻译： 本发明涉及大环HCV蛋白酶抑制剂，大环非核苷HCV聚合酶抑制剂和核苷HCV聚合酶抑制剂的组合。
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![CARBOXAMIDE 4-[(4-PYRIDYL)AMINO]PYRIMIDINES USEFUL AS HCV INHIBITORS](/abs-image/US/2009/10/01/US20090247523A1/abs.jpg.150x150.jpg)
9.发明申请CARBOXAMIDE 4-[(4-PYRIDYL)AMINO]PYRIMIDINES USEFUL AS HCV INHIBITORS 有权碳酰胺4 - [（4-吡啶基）氨基]嘧啶可用作HCV抑制剂公开(公告)号：US20090247523A1
公开(公告)日：2009-10-01
申请号：US12443190
申请日：2007-10-04
IPC分类号： A61K31/5377 , C07D401/12 , A61K31/506 , C07D413/14 , A61P31/12
CPC分类号： A61K31/506 , A61K31/535 , A61K2300/00
摘要： The present invention relates to the use of carboxamide 4-[(4-pyridyl)amino]-pyrimidines as inhibitors of HCV replication as well as their use in pharmaceutical compositions aimed to treat or combat HCV infections.
摘要翻译： 本发明涉及羧酰胺4 - [（4-吡啶基）氨基] - 嘧啶作为HCV复制的抑制剂的用途，以及它们在旨在治疗或对抗HCV感染的药物组合物中的用途。
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公开(公告)号：US20070155716A1
公开(公告)日：2007-07-05
申请号：US11684288
申请日：2007-03-09
申请人： Kenneth SIMMEN , Tse-I Lin , Oliver Lenz , Dominique Louis Surleraux , Pierre Jean-Marie Raboisson
发明人： Kenneth SIMMEN , Tse-I Lin , Oliver Lenz , Dominique Louis Surleraux , Pierre Jean-Marie Raboisson
IPC分类号： A61K31/55 , A61K31/519 , A61K31/541 , A61K31/5377
CPC分类号： A61K31/517 , A61K31/519 , A61K31/52 , A61K31/53 , A61K31/5377 , Y02A50/385 , Y02A50/387
摘要： The present invention relates to the use of bi-cyclic pyrimidines as inhibitors of HCV replication as well as their use in pharmaceutical compositions aimed to treat or combat HCV infections. In addition, the present invention relates to processes for preparation of such pharmaceutical compositions. The present invention also concerns combinations of the present bi-cyclic pyrimidines with other anti-HCV agents.
摘要翻译： 本发明涉及双环嘧啶作为HCV复制抑制剂的用途，以及它们在旨在治疗或对抗HCV感染的药物组合物中的用途。 此外，本发明涉及这种药物组合物的制备方法。 本发明还涉及本发明的双环嘧啶与其它抗HCV药物的组合。
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