公开(公告)号：US20240189446A1

公开(公告)日：2024-06-13

申请号：US18263793

申请日：2022-02-23

Applicant: Poseida Therapeutics, Inc.

Inventor： Joshua RYCHAK ,  Sean ESSEX ,  Matthew BUTCHER ,  Peter GRIFFIN ,  Blair MADISON ,  Renata MARTIN ,  Neha PARAYATH ,  Michael J. BENNETT ,  Khalid A. HAJJ ,  Oscar ALVAREZ ,  Dan J. SMITH

IPC: A61K48/00 ,  A61K9/51 ,  A61K31/7088 ,  A61K38/18 ,  A61K38/37 ,  A61K38/45 ,  A61K38/46 ,  A61K38/48 ,  A61P7/04

CPC classification number: A61K48/0041 ,  A61K9/5123 ,  A61K9/5146 ,  A61K31/7088 ,  A61K38/1816 ,  A61K38/37 ,  A61K38/45 ,  A61K38/465 ,  A61K38/4846 ,  A61P7/04 ,  C12Y201/03003 ,  C12Y304/21022

Abstract: The present disclosure provides compositions and methods for the genetic modification of cells, including, but not limited to, hepatocytes. The compositions and methods can comprise lipid nanoparticles, wherein the lipid nanoparticles comprise at least one bioreducible ionizable cationic lipid, at least one structural lipid, at least one phospholipid and at least one PEGylated lipid.