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1.发明授权公开(公告)号：US08846088B2
公开(公告)日：2014-09-30
申请号：US11883532
申请日：2006-02-02
CPC分类号： A61K9/1623 , A61K9/1694 , A61K9/2018
摘要： A novel method for the preparation of a tablet comprising a calcium-containing compound, the method involves a melt granulation process by which a sugar alcohol is melted and embeds the calcium-containing compound so that a sufficient taste masking of the chalkiness is substantially achieved and an unpleasant mouth feel of the calcium-containing compound is substantially avoided, while at the same time obtaining a low tablet volume. The method of the invention is especially suitable for the manufacturing of tablets having a high load of a calcium-containing compound.
摘要翻译： 一种用于制备包含含钙化合物的片剂的新方法，所述方法包括熔融制粒方法，通过该方法将糖醇熔融并包埋含钙化合物，使得基本上实现了足够的垩白味道掩蔽， 基本上避免了含钙化合物的令人不愉快的口感，同时获得低的片剂体积。 本发明的方法特别适用于制造具有高负荷的含钙化合物的片剂。
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2.发明授权公开(公告)号：US08808735B2
公开(公告)日：2014-08-19
申请号：US11883536
申请日：2006-02-02
CPC分类号： A61K9/1623 , A61K9/1694 , A61K9/2018
摘要： The present invention relates to a novel process for the preparation of a granulate comprising a calcium-containing compound as an active substance. The method comprises a method for the preparation of a granulate comprising a calcium-containing compound as an active substance, the method comprising, i) feeding a granulation chamber with a composition comprising the calcium-containing compound, ii) wet-massing the composition with a granulation liquid optionally comprising a pharmaceutically acceptable binder for a time period of at the most 30 sec to obtain a wet granulate, iii) drying the thus obtained wet granulate. A granulate obtained by the present method is especially suitable in the preparation of solid dosage forms, in particular in the preparation of tablets.
摘要翻译： 本发明涉及一种制备包含含钙化合物作为活性物质的颗粒的新方法。 该方法包括用于制备包含含钙化合物作为活性物质的颗粒的方法，所述方法包括：i）向含有含钙化合物的组合物喂养造粒室，ii）将组合物湿化， 任选地包含药学上可接受的粘合剂的造粒液，时间为最多30秒以获得湿颗粒，iii）干燥由此获得的湿颗粒。 通过本方法获得的颗粒特别适用于制备固体剂型，特别是制备片剂。
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公开(公告)号：US10258576B2
公开(公告)日：2019-04-16
申请号：US11597454
申请日：2005-05-24
摘要： The present invention relates to a particulate material and a solid dosage form notably tablets comprising a regularly shaped calcium-containing compound such as a calcium salt as a therapeutically and/or prophylactically active substance and a pharmaceutically acceptable sugar alcohol such as, e.g., sorbitol and/or isomalt that has a micro structure as evidenced by SEM. The invention also relates to a process for the preparation of the particulate material and solid dosage form. The process involves agglomeration of the calcium-containing compound and the pharmaceutically acceptable sugar alcohol by means of roller compaction. The particulate material obtained by roller compaction is suitable for use in the further processing of the particulate material into e.g. tablets such as chewing tablets.
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公开(公告)号：USD564086S1
公开(公告)日：2008-03-11
申请号：US29243701
申请日：2005-11-29
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