公开(公告)号：US06376683B1

公开(公告)日：2002-04-23

申请号：US09872849

申请日：2001-06-01

Applicant: Pradeep Kumar ,  Rodney Agustinho Fernandes

Inventor： Pradeep Kumar ,  Rodney Agustinho Fernandes

IPC: C07D30930

CPC classification number: C07D309/30 ,  Y02P20/582

Abstract: The present invention relates to an improved, efficient and enantio-selective process for the synthesis of (4R, 6S)-4-hydroxy-6-hydroxymethyl tetrahydropyran-2-one, employing the Sharpless asymmetric dihydroxylation and regiospecific nucleophilic hydride opening of the cyclic sulfite/sulfate as the key steps. The invention also resides in the intermediates used in the process.

Abstract translation: 本发明涉及一种用于合成（4R，6S）-4-羟基-6-羟甲基四氢吡喃-2-酮的改进的，有效的和对映体选择性方法，采用Sharpless不对称二羟基化和区域特异性亲核氢化物开环的环状 亚硫酸盐/硫酸盐为关键步骤。 本发明也在于该方法中使用的中间体。

公开(公告)号：US06825378B2

公开(公告)日：2004-11-30

申请号：US10400653

申请日：2003-03-28

Applicant: Pradeep Kumar ,  Rodney Agustinho Fernandes ,  Priti Gupta

Inventor： Pradeep Kumar ,  Rodney Agustinho Fernandes ,  Priti Gupta

IPC: C07C57030

CPC classification number: C07C59/54 ,  C07B2200/07 ,  C07C29/03 ,  C07C45/29 ,  C07C47/27 ,  C07C51/29 ,  C07C2601/14 ,  Y02P20/582 ,  C07C33/36

Abstract: The present invention provides a process for the synthesis of enantiomerically pure cyclohexylphenyl glycolic acid of formula (1). The present invention more particularly relates to a process using cyclohexylphenyl ketone for the synthesis of enantiomerically pure cyclohexylphenyl glycolic acid of formula (1).

Abstract translation: 本发明提供了合成式（1）的对映体纯的环己基苯基乙醇酸的方法。 本发明更具体地涉及使用环己基苯基酮合成式（1）的对映体纯的环己基苯基乙醇酸的方法。