公开(公告)号：US20170037055A1

公开(公告)日：2017-02-09

申请号：US15304740

申请日：2015-04-19

申请人： Prasada Raju Vetukuri Vnkv ,  Goverdhan Gilla ,  Ambaiah Boini ,  Krishna Prasad Chigurupati ,  Grannules India Limited

发明人： Prasada Raju Vetukuri Vnkv ,  Goverdhan Gilla ,  Ambaiah Boini ,  Krishna Prasad Chigurupati

IPC分类号： C07D498/22

CPC分类号： C07D498/22 ,  C07B2200/13

摘要： The present invention relates to an improved and industrially advantageous process for the preparation of Rifaximin with high purity and yield. Particularly, the present invention relates to improved processes for the preparation of Rifaximin from Rifamycin O and S. More particularly the present invention relates to a process for the preparation of Rifaximin through 3-halorifamycin S. The present invention further relates to a novel polymorph of Rifaximin and process for its preparation.

摘要翻译： 本发明涉及一种用于制备具有高纯度和产率的利福昔明的改进和工业上有利的方法。 特别地，本发明涉及从利福霉素O和S制备利福昔明的改进方法。更具体地说，本发明涉及通过3-卤代霉素S制备利福昔明的方法。本发明还涉及一种新型多晶型物 利福昔明及其制备方法。

公开(公告)号：US10385006B2

公开(公告)日：2019-08-20

申请号：US15518498

申请日：2015-10-26

申请人： GRANULES INDIA LIMITED ,  Krishna Prasad Chigurupati ,  Prasad Raju Vnkv Vetukuri

发明人： Krishna Prasad Chigurupati ,  Prasad Raju Vnkv Vetukuri ,  Goverdhan Gilla ,  Rajasekhar Bhupathi

IPC分类号： C07C51/41 ,  C07C213/00 ,  C07C213/08 ,  C07C213/10 ,  C07D473/16 ,  C07C51/42

摘要： The present invention relates to a process for the preparation of amino alcohol derivatives or salts thereof which may be used as intermediates in the preparation of HIV reverse transcriptase inhibitors, more preferably Carbovir and Abacavir. The present invention more specifically relates to a process for the preparation of (1S, 4R)-4-amino-2-cyclopentene-1-methanol of Formula IIIa.