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公开(公告)号：US11702423B2
公开(公告)日：2023-07-18
申请号：US17343341
申请日：2021-06-09
发明人： Hong Lin , Philip Pitis , Liang Lu , Andrew Paul Combs
IPC分类号： C07D401/12 , A61K31/50 , A61P35/00 , C07D487/14 , C07D519/00
CPC分类号： C07D487/14 , C07D519/00
摘要： The present disclosure provides bifunctional compounds comprising a target protein binding moiety and a E3 ubiquitin ligase binding moiety, and associated methods of use.
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公开(公告)号：US20220152072A1
公开(公告)日：2022-05-19
申请号：US17601479
申请日：2020-04-03
发明人： Hong Lin , Juan Luengo , Rupa Shetty , Michael Hawkins
IPC分类号： A61K31/7064
摘要： The disclosure is directed to methods of treating disease using compounds of Formula (I).
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公开(公告)号：US20200291037A1
公开(公告)日：2020-09-17
申请号：US16888883
申请日：2020-06-01
发明人： Juan Luengo , Hong Lin , Michael Hawkins , Rupa Shetty , Philip Pitis , Gisela Saborit Villarroya
IPC分类号： C07D487/04 , A61P35/00 , C07D519/00
摘要： The disclosure is directed to compounds of Formula I Pharmaceutical compositions comprising compounds of Formula I, as well as methods of their use and preparation, are also described.
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公开(公告)号：US20220153747A1
公开(公告)日：2022-05-19
申请号：US17529781
申请日：2021-11-18
发明人： Hong Lin , Juan Luengo , Rupa Shetty , Michael Hawkins
IPC分类号： C07D487/04 , C07H19/14 , A61K31/7064 , A61P35/02 , C07D519/00
摘要： The disclosure is directed to compounds of Formula I Pharmaceutical compositions comprising compounds of Formula I, as well as methods of their use and preparation, are also described.
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公开(公告)号：US20190284193A1
公开(公告)日：2019-09-19
申请号：US16376100
申请日：2019-04-05
发明人： Juan Luengo , Hong Lin , Michael Hawkins , Rupa Shetty , Philip Pitus , Gisela Saborit Villarroya
IPC分类号： C07D487/04 , C07D519/00 , A61P35/00
摘要： The disclosure is directed to compounds of Formula I Pharmaceutical compositions comprising compounds of Formula I, as well as methods of their use and preparation, are also described.
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公开(公告)号：US20220152073A1
公开(公告)日：2022-05-19
申请号：US17601485
申请日：2020-04-03
发明人： Hong Lin , Juan Luengo , Rupa Shetty , Michael Hawkins , Philip Pitis , Gisela Saborit Villarroya
IPC分类号： A61K31/7064
摘要： The disclosure is directed to methods of treatment using compounds of Formula (I).
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公开(公告)号：US11214574B2
公开(公告)日：2022-01-04
申请号：US16888883
申请日：2020-06-01
发明人： Juan Luengo , Hong Lin , Michael Hawkins , Rupa Shetty , Philip Pitis , Gisela Saborit Villarroya
IPC分类号： C07D487/04 , C07D519/00 , A61P35/00
摘要： The disclosure is directed to compounds of Formula I Pharmaceutical compositions comprising compounds of Formula I, as well as methods of their use and preparation, are also described.
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公开(公告)号：US11208416B2
公开(公告)日：2021-12-28
申请号：US16985643
申请日：2020-08-05
发明人： Hong Lin , Juan Luengo , Rupa Shetty , Michael Hawkins
IPC分类号： C07D487/04 , C07H19/14 , A61K31/7064 , A61P35/02 , C07D519/00
摘要： The disclosure is directed to compounds of Formula I Pharmaceutical compositions comprising compounds of Formula I, as well as methods of their use and preparation, are also described.
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公开(公告)号：US11078205B2
公开(公告)日：2021-08-03
申请号：US16744771
申请日：2020-01-16
发明人： Hong Lin , Juan Luengo , Rupa Shetty , Michael Hawkins
IPC分类号： C07D487/04 , C07D519/00 , A61P35/02 , A61K31/7064 , C07H19/14
摘要： The disclosure is directed to compounds of Formula I Pharmaceutical compositions comprising compounds of Formula I, as well as methods of their use and preparation, are also described.
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公开(公告)号：US10570140B2
公开(公告)日：2020-02-25
申请号：US16059909
申请日：2018-08-09
发明人： Hong Lin , Juan Luengo , Rupa Shetty , Michael Hawkins
IPC分类号： C07D487/04 , C07D519/00 , A61P35/02
摘要： The disclosure is directed to compounds of Formula I Pharmaceutical compositions comprising compounds of Formula I, as well as methods of their use and preparation, are also described.
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