公开(公告)号：US20230219898A1

公开(公告)日：2023-07-13

申请号：US18010642

申请日：2021-06-16

Applicant: President and Fellows of Harvard College

Inventor： Junying Yuan ,  Heng Zhao ,  Daichao Xu ,  Mingzhi Jin ,  Hong Zhu ,  Gregory D. Cuny

IPC: C07D233/42 ,  C07D233/26 ,  C07C335/32 ,  C07D401/12 ,  C07D295/195 ,  C07D207/08 ,  A61K31/4178 ,  A61K31/4184

CPC classification number: C07D233/42 ,  C07D233/26 ,  C07C335/32 ,  C07D401/12 ,  C07D295/195 ,  C07D207/08 ,  A61K31/4178 ,  A61K31/4184

Abstract: Disclosed herein are small molecules that inhibit apoptosis and promote autophagy through the TRADD pathway, and their use for treatment of neurodegenerative diseases. Methods of preparing these small molecules and medicinal efficacy are described.