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公开(公告)号：US20250145956A1
公开(公告)日：2025-05-08
申请号：US18684234
申请日：2022-07-01
Applicant: President and Fellows of Harvard College
Inventor： John F. Zimmerman , Huibin Chang , Kevin Kit Parker
Abstract: Methods of evaluating functional activity of an engineered three-dimensional tissue, methods of identifying a compound that modulates tissue function, and methods for identifying a compounds that is useful for treating or preventing a disease affecting tissue function are provided herein. Some methods include providing or obtaining a three-dimensional tissue scaffold defining a lumen or a cavity, the tissue scaffold comprising one or more polymeric fibers each having a micron-scale or nanometer-scale diameter, at least some of the one or more polymeric fibers encircling the lumen or cavity at a helical angle with respect to a longitudinal axis of the lumen or cavity, at an azimuthal orientation with respect to the longitudinal axis of the lumen or cavity, or at both.
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公开(公告)号：US20250034759A1
公开(公告)日：2025-01-30
申请号：US18910120
申请日：2024-10-09
Applicant: President and Fellows of Harvard College
Inventor： Qihan Liu , Kevin Kit Parker , Huibin Chang
Abstract: Systems and methods for focused direction deposition of a micron or nanometer dimension polymeric fiber and materials of such fibers are described herein. Systems and methods employ one or more gas flows to entrain and deflect fibers produced by a rotary jet spinning system forming a focused fiber stream. Some embodiments enable control of alignment and distribution of the fibers with a relatively high fiber throughput.
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公开(公告)号：US12139821B2
公开(公告)日：2024-11-12
申请号：US17421047
申请日：2020-01-14
Applicant: President and Fellows of Harvard College
Inventor： Qihan Liu , Kevin Kit Parker , Huibin Chang
Abstract: Systems and methods for focused direction deposition of a micron or nanometer dimension polymeric fiber and materials of such fibers are described herein. Systems and methods employ one or more gas flows to entrain and deflect fibers produced by a rotary jet spinning system forming a focused fiber stream. Some embodiments enable control of alignment and distribution of the fibers with a relatively high fiber throughput.
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公开(公告)号：US20220090300A1
公开(公告)日：2022-03-24
申请号：US17421047
申请日：2020-01-14
Applicant: President and Fellows of Harvard College
Inventor： Qihan Liu , Kevin Kit Parker , Huibin Chang
Abstract: Systems and methods for focused direction deposition of a micron or nanometer dimension polymeric fiber and materials of such fibers are described herein. Systems and methods employ one or more gas flows to entrain and deflect fibers produced by a rotary jet spinning system forming a focused fiber stream. Some embodiments enable control of alignment and distribution of the fibers with a relatively high fiber throughput.
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