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公开(公告)号：US20250134968A1
公开(公告)日：2025-05-01
申请号：US19015746
申请日：2025-01-10
Applicant: Protalix Ltd.
Inventor： Einat ALMON , Raul CHERTKOFF , Sari ALON , Yoseph SHAALTIEL
Abstract: Methods of treating Fabry disease via administration of stabilized plant recombinant human alpha galactosidase protein comprising at least two alpha-galactosidase monomers being covalently linked to one another via a linking moiety, and unit dosages of protein are disclosed herein. The disclosed protocols are safe, have greater than 2 week intervals between administrations and exhibit important improvement in patient's disease parameters, in terms of reduced Gb3 accumulation, pain and GI parameters, kidney and cardiac stabilization in the clinical setting.
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公开(公告)号：US20200155654A1
公开(公告)日：2020-05-21
申请号：US16476084
申请日：2018-01-05
Applicant: Protalix Ltd.
Inventor： Einat ALMON , Raul CHERTKOFF , Sari ALON , Yoseph SHAALTIEL
Abstract: Methods of treating Fabry disease via administration of stabilized plant recombinant human alpha galactosidase protein comprising at least two alpha-galactosidase monomers being covalently linked to one another via a linking moiety, and unit dosages of protein are disclosed herein. The disclosed protocols are safe, have greater than 2 week intervals between administrations and exhibit important improvement in patient's disease parameters, in terms of reduced Gb3 accumulation, pain and GI parameters, kidney and cardiac stabilization in the clinical setting.
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