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公开(公告)号：US20220089702A1
公开(公告)日：2022-03-24
申请号：US16500251
申请日：2018-05-02
申请人： Robin BARBOUR , Svetlana ALEXANDER , Mark E. RENZ , Shuning GAI , Tarlochan NIJJAR , Philip James DOLAN , Philip PAYNE , PROTHENA BIOSCIENCES LIMITED
发明人： Robin BARBOUR , Svetlana ALEXANDER , Mark RENZ , Shuning GAI , Tarlochan S. NIJJAR , Philip James DOLAN, III , Philip PAYNE
IPC分类号： C07K16/18
摘要： The invention provides antibodies that specifically bind tau. The antibodies inhibit or delay tau-associated pathologies and associated symptomatic deterioration.
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公开(公告)号：US20240309078A1
公开(公告)日：2024-09-19
申请号：US18601222
申请日：2024-03-11
发明人： Robin BARBOUR , Svetlana ALEXANDER , Mark E. RENZ , Shuning GAI , Tarlochan S. NIJJAR , Philip James DOLAN, III , Philip PAYNE
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , C07K2317/24 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The invention provides antibodies that specifically bind tau. The antibodies inhibit or delay tau-associated pathologies and associated symptomatic deterioration.
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公开(公告)号：US20210017278A1
公开(公告)日：2021-01-21
申请号：US17040343
申请日：2019-03-22
IPC分类号： C07K16/28
摘要： Methods for the treatment of AL amyloidosis associated with the deposition of misfolded immunoglobulin light chain proteins and corresponding uses related to an antibody, such as a 2A4 antibody, or a pharmaceutical formulation comprising the antibody.
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公开(公告)号：US20220275067A1
公开(公告)日：2022-09-01
申请号：US17429288
申请日：2020-02-07
发明人： Philip James DOLAN, III , Tarlochan S. NIJJAR , Svetlana ALEXANDER , Robin BARBOUR , Stephen Jed TAM
IPC分类号： C07K16/18
摘要： The invention provides antibodies that specifically bind tau. The antibodies inhibit or delay tau-associated pathologies and associated symptomatic deterioration.
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公开(公告)号：US20220153821A1
公开(公告)日：2022-05-19
申请号：US17291986
申请日：2019-11-08
发明人： Tarlochan S. NIJJAR , Robin BARBOUR , Philip James DOLAN, III , Yue LIU , Svetlana ALEXANDER , Mark E. RENZ
摘要： The invention provides antibodies that specifically bind tau. The antibodies inhibit or delay tau-associated pathologies and associated symptomatic deterioration.
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公开(公告)号：US20230235048A1
公开(公告)日：2023-07-27
申请号：US18011764
申请日：2021-06-23
IPC分类号： C07K16/28
CPC分类号： C07K16/28 , C07K2317/565 , C07K2317/24 , C07K2317/76
摘要： The invention provides antibodies that specifically bind sortilin. The antibodies inhibit or delay pathologies associated with changes in progranulin levels and associated symptomatic deterioration.
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公开(公告)号：US20200331992A1
公开(公告)日：2020-10-22
申请号：US16753307
申请日：2018-10-05
发明人： Joshua Reginald SALMANS , Svetlana ALEXANDER , Robin BARBOUR , Jeffrey N. HIGAKI , Tarlochan S. NIJJAR
IPC分类号： C07K16/18 , A61K31/713
摘要： The invention provides antibodies that specifically bind to transthyretin (TTR). The antibodies can be used for treating or effecting prophylaxis of diseases or disorders associated with TTR accumulation or accumulation of TTR deposits (e.g., TTR amyloidosis). The antibodies can also be used for diagnosing TTR amyloidosis and inhibiting or reducing aggregation of TTR, and for monitoring the efficacy of TTR therapies, among other applications.
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公开(公告)号：US20200249244A1
公开(公告)日：2020-08-06
申请号：US16753661
申请日：2018-10-05
发明人： Joshua Reginald SALMANS , Svetlana ALEXANDER , Robin BARBOUR , Jianmin LI , Jeffrey N. HIGAKI , Tarlochan S. NIJJAR
IPC分类号： G01N33/68 , A61K39/395 , A61K49/00 , G01N33/543 , G01N33/58 , G01N21/76 , G01N21/66
摘要： The invention provides methods of detecting transthyretin (TTR) using a capture antibody and a reporter antibody. The capture antibody binds preferentially to misfolded TTR over native tetrameric form of TTR. The capture antibody binds to an epitope within amino acid residues 89-97 or TTR or to an epitope within amino acid residues 101-109 of TTR. 9D5 and 18C5 are examples of suitable capture antibodies. The methods can be used for diagnosing diseases or disorders associated with TTR accumulation or accumulation of TTR deposits (e.g., TTR amyloidosis) and for monitoring the efficacy of TTR therapies, among other applications.
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