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    METHOD OF MAKING SOLANACEAE FRUIT EXTRACTS
    1.
    发明申请
    METHOD OF MAKING SOLANACEAE FRUIT EXTRACTS 有权

    公开(公告)号：US20210330732A1

    公开(公告)日：2021-10-28

    申请号：US17192155

    申请日：2021-03-04

    申请人： Provexis Natural Products Limited

    发明人： Niamh O'Kennedy

    IPC分类号： A61K36/81 ,  A61K31/7048 ,  A61K31/7064

    摘要： Provided are methods of making an extract of fruit of the Solanaceae family wherein fruit is processed to optimise the platelet aggregation inhibiting activity of the extract. The methods involve preparing a start mix of homogenised fruit; separating a water soluble fraction from fruit solids; filtration of the water soluble fraction; and concentration of active agents in the filtration permeate. The invention also provides fruit extracts manufactured by such methods, and also fruit extracts containing glycosylated phenolic acid or a phenolic ester, or derivatives thereof; a glycosylated flavonoid; and a nucleoside. The extracts of the invention are useful as medicaments for the treatment or prevention of a medical condition characterised by inappropriate platelet aggregation. In particular, the medicaments may be of use in maintaining heart health by reducing platelet aggregation; benefiting the circulation; and/or normalizing or otherwise benefiting blood flow.

    THERAPEUTIC COMPOSITIONS COMPRISING PHENOLIC ACIDS FOR TREATING CONDITIONS RELATED TO INAPPROPRIATE PLATELET AGGREGATION
    2.
    发明申请
    THERAPEUTIC COMPOSITIONS COMPRISING PHENOLIC ACIDS FOR TREATING CONDITIONS RELATED TO INAPPROPRIATE PLATELET AGGREGATION 审中-公开
    包含酚醛类化合物的治疗组合物用于处理与不合适的细胞聚集相关的条件

    公开(公告)号：US20150105338A1

    公开(公告)日：2015-04-16

    申请号：US14333787

    申请日：2014-07-17

    申请人： PROVEXIS NATURAL PRODUCTS LIMITED

    发明人： Niamh O'Kennedy

    IPC分类号： A61K31/192 ,  A61K31/353 ,  A61K31/7048 ,  A61K47/48

    CPC分类号： A61K31/192 ,  A61K31/216 ,  A61K31/235 ,  A61K31/353 ,  A61K31/7034 ,  A61K31/7048 ,  A61K45/06 ,  A61K47/549

    摘要： The invention provides compositions comprising a therapeutically effective amount of a compound of general formula (I): wherein R1, R2 and R3 may be independently selected from H, OH and OMe; wherein X is C1 or C2 and wherein for C2 each carbon is linked by a single or multiple bond (preferably a double bond) and is substituted with one or more H or OH, for use as a medicament for treating or preventing the development of medical conditions characterised by inappropriate platelet aggregation. The compositions of the invention may be used to maintain heart health by reducing platelet aggregation; benefit the circulation; and/or normalize or otherwise benefit blood flow.

    摘要翻译： 本发明提供包含治疗有效量的通式（I）的化合物的组合物：其中R 1，R 2和R 3可以独立地选自H，OH和OMe; 其中X是C1或C2，其中对于C2，每个碳通过单键或多重键（优选双键）连接并被一个或多个H或OH取代，用作治疗或预防医学发展的药物 以不合适的血小板聚集为特征的病症。 本发明的组合物可用于通过减少血小板聚集来维持心脏健康; 有利于流通; 和/或使血液流通正常化或以其他方式受益。

    Method of making solanaceae fruit extracts
    4.
    发明授权
    Method of making solanaceae fruit extracts 有权

    公开(公告)号：US10973865B2

    公开(公告)日：2021-04-13

    申请号：US15866900

    申请日：2018-01-10

    申请人： Provexis Natural Products Limited

    发明人： Niamh O'Kennedy

    IPC分类号： A61K36/81 ,  A61K31/7048 ,  A61K31/7064

    摘要： Provided are methods of making an extract of fruit of the Solanaceae family wherein fruit is processed to optimise the platelet aggregation inhibiting activity of the extract. The methods involve preparing a start mix of homogenised fruit; separating a water soluble fraction from fruit solids; filtration of the water soluble fraction; and concentration of active agents in the filtration permeate. The invention also provides fruit extracts manufactured by such methods, and also fruit extracts containing glycosylated phenolic acid or a phenolic ester, or derivatives thereof, a glycosylated flavonoid; and a nucleoside. The extracts of the invention are useful as medicaments for the treatment or prevention of a medical condition characterised by inappropriate platelet aggregation. In particular, the medicaments may be of use in maintaining heart health by reducing platelet aggregation; benefiting the circulation, and/or normalizing or otherwise benefiting blood flow.

    FRUIT EXTRACTS
    5.
    发明申请
    FRUIT EXTRACTS 审中-公开
    水果提取物

    公开(公告)号：US20140147537A1

    公开(公告)日：2014-05-29

    申请号：US14030533

    申请日：2013-09-18

    申请人： Provexis Natural Products Limited

    发明人： Niamh O'Kennedy

    IPC分类号： A61K36/81 ,  A61K31/7064 ,  A61K31/7048

    摘要： Provided are methods of making an extract of fruit of the Solanaceae family wherein fruit is processed to optimise the platelet aggregation inhibiting activity of the extract. The methods involve preparing a start mix of homogenised fruit; separating a water soluble fraction from fruit solids; filtration of the water soluble fraction; and concentration of active agents in the filtration permeate. The invention also provides fruit extracts manufactured by such methods, and also fruit extracts containing glycosylated phenolic acid or a phenolic ester, or derivatives thereof, a glycosylated flavonoid; and a nucleoside. The extracts of the invention are useful as medicaments for the treatment or prevention of a medical condition characterised by inappropriate platelet aggregation. In particular, the medicaments may be of use in maintaining heart health by reducing platelet aggregation; benefiting the circulation; and/or normalizing or otherwise benefiting blood flow.

    摘要翻译： 提供制造茄科的果实提取物的方法，其中加工水果以优化提取物的血小板聚集抑制活性。 该方法包括制备均质水果的起始混合物; 从水果固体中分离出水溶性部分; 过滤水溶性部分; 和过滤渗透物中活性剂的浓度。 本发明还提供了通过这些方法制造的水果提取物，还包括含有糖基化的酚酸或酚酯或其衍生物的糖果类黄酮的果实提取物; 和核苷。 本发明的提取物可用作治疗或预防以血小板聚集不当为特征的医学病症的药物。 特别地，药物可用于通过减少血小板聚集来维持心脏健康; 有利于流通; 和/或使血液流动正常化或以其他方式受益。

    FRUIT EXTRACTS
    8.
    发明申请
    FRUIT EXTRACTS 审中-公开

    公开(公告)号：US20180256666A1

    公开(公告)日：2018-09-13

    申请号：US15866900

    申请日：2018-01-10

    申请人： Provexis Natural Products Limited

    发明人： Niamh O'Kennedy

    IPC分类号： A61K36/81 ,  A61K31/7064 ,  A61K31/7048

    摘要： Provided an methods of making an extract of fruit of the Solanaceae family wherein fruit is processed to optimise the platelet aggregation inhibiting activity of the extract. The methods involve preparing a start mix of homogenised fruit; separating a water soluble fraction from fruit solids; filtration of the water soluble fraction; and concentration of active agents in the filtration permeate. The invention also provides fruit extracts manufactured by such methods, and also fruit extracts containing glycosylated phenolic acid or a phenolic ester, or derivatives thereof, a glycosylated flavonoid; and a nucleoside. The extracts of the invention are useful as medicaments for the treatment or prevention of a medical condition characterised by inappropriate platelet aggregation. In particular, the medicaments may be of use in maintaining heart health by reducing platelet aggregation; benefiting the circulation, and/or normalizing or otherwise benefiting blood flow.