公开(公告)号：US10438688B2

公开(公告)日：2019-10-08

申请号：US16113718

申请日：2018-08-27

Applicant: Purdue Research Foundation

Inventor： Marxa L. Figueiredo ,  Charles Samuel Umbaugh ,  Herman O. Sintim ,  Adriana Diaz-Quinones

IPC: A61K31/497 ,  G16B15/00 ,  A61P19/02 ,  A61P35/00 ,  G16B35/00 ,  G16C20/60

Abstract: An in silico screening method generated compounds that are against laminin receptor 37LR and their anti-cancer functions in prostate cancer cell lines are disclosed herein. A group of derivatives based on the hit compound from the in silico screening are synthesized and tested with improved IC50 value that can have relevant clinical use for prostate cancer or osteoarthritis.

公开(公告)号：US11022604B2

公开(公告)日：2021-06-01

申请号：US16555486

申请日：2019-08-29

Applicant: Purdue Research Foundation

Inventor： Marxa L. Figueiredo ,  Charles Samuel Umbaugh ,  Herman O. Sintim ,  Adriana Diaz-Quinones

IPC: G01N33/50 ,  G01N33/574 ,  G16B15/30 ,  G16C20/60 ,  G16C20/50 ,  A61K31/497

Abstract: An in silico screening method generated compounds that are against laminin receptor 37LR and their anti-cancer functions in prostate cancer cell lines are disclosed herein. A group of derivatives based on the hit compound from the in silico screening are synthesized and tested with improved IC50 value that can have relevant clinical use for prostate cancer or osteoarthritis.

公开(公告)号：US20200064334A1

公开(公告)日：2020-02-27

申请号：US16555486

申请日：2019-08-29

Applicant: Purdue Research Foundation

Inventor： Marxa L. Figueiredo ,  Charles Samuel Umbaugh ,  Herman O. Sintim ,  Adriana Diaz-Quinones

IPC: G01N33/50 ,  G01N33/574 ,  A61K31/497 ,  G16C20/60 ,  G16C20/50 ,  G16B15/30

Abstract: An in silico screening method generated compounds that are against laminin receptor 37LR and their anti-cancer functions in prostate cancer cell lines are disclosed herein. A group of derivatives based on the hit compound from the in silico screening are synthesized and tested with improved IC50 value that can have relevant clinical use for prostate cancer or osteoarthritis.

公开(公告)号：US20190065669A1

公开(公告)日：2019-02-28

申请号：US16113718

申请日：2018-08-27

Applicant: Purdue Research Foundation

Inventor： Marxa L. Figueiredo ,  Charles Samuel Umbaugh ,  Herman O. Sintim ,  Adriana Diaz-Quinones

IPC: G06F19/16 ,  C40B30/02 ,  A61K31/497 ,  A61P35/00 ,  A61P19/02

CPC classification number: G16B15/00 ,  A61K31/497 ,  A61P19/02 ,  A61P35/00 ,  G16B15/30 ,  G16B35/00 ,  G16C20/50 ,  G16C20/60 ,  G16C20/64

Abstract: An in silico screening method generated compounds that are against laminin receptor 37 LR and their anti-cancer functions in prostate cancer cell lines are disclosed herein. A group of derivatives based on the hit compound from the in silico screening are synthesized and tested with improved IC50 value that can have relevant clinical use for prostate cancer or osteoarthritis.