公开(公告)号：US20230293523A1

公开(公告)日：2023-09-21

申请号：US18200419

申请日：2023-05-22

Applicant: Purdue Research Foundation

Inventor： Daniel P. Flaherty ,  Richard M. van Rijn ,  Val J. Watts ,  Jason A. Scott

IPC: A61K31/506 ,  C07D403/04

CPC classification number: A61K31/506 ,  C07D403/04

Abstract: The present invention relates to a method of treatment for chronic pain, opioid dependence, alcohol use disorder or autism using a class of pyrimidinone compounds, an adenylyl cyclase 1 (AC1) inhibitor. The invention described herein also pertains to pharmaceutical compositions and methods for treating diseases in mammals using those compounds disclosed herein.

公开(公告)号：US11690844B2

公开(公告)日：2023-07-04

申请号：US17063747

申请日：2020-10-06

Applicant: Purdue Research Foundation

Inventor： Daniel P. Flaherty ,  Richard M. van Rijn ,  Val J. Watts ,  Jason A. Scott

IPC: C07D403/04 ,  A61K31/506

CPC classification number: A61K31/506 ,  C07D403/04

Abstract: The present invention relates to a method of treatment for chronic pain, opioid dependence, alcohol use disorder or autism using a class of pyrimidinone compounds, an adenylyl cyclase 1 (AC1) inhibitor. The invention described herein also pertains to pharmaceutical compositions and methods for treating diseases in mammals using those compounds disclosed herein.

公开(公告)号：US20210100797A1

公开(公告)日：2021-04-08

申请号：US17063747

申请日：2020-10-06

Applicant: Purdue Research Foundation

Inventor： Daniel P. Flaherty ,  Richard M. van Rijn ,  Val J. Watts ,  Jason A. Scott

IPC: A61K31/506 ,  C07D403/04

Abstract: The present invention relates to a method of treatment for chronic pain, opioid dependence, alcohol use disorder or autism using a class of pyrimidinone compounds, an adenylyl cyclase 1 (AC1) inhibitor. The invention described herein also pertains to pharmaceutical compositions and methods for treating diseases in mammals using those compounds disclosed herein.