公开(公告)号：US20190160035A1

公开(公告)日：2019-05-30

申请号：US16320762

申请日：2017-07-28

申请人： QBIOTICS LIMITED

发明人： Peter Gordon PARSONS ,  Peter Frederick SCHMIDT ,  Charles Stewart LOWDEN ,  Justine Emma CAMPBELL ,  Victoria GORDON

IPC分类号： A61K31/336 ,  A61K31/495 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/5415 ,  A61K31/137 ,  A61K31/426 ,  A61K31/573 ,  A61K9/06 ,  A61K9/00 ,  A61K47/34 ,  A61P35/00

摘要： The present invention relates to methods of treating mast cell tumors and soft tissue sarcomas using 6,7-epoxy-4,5,9,12,13,20-hexahydroxy-1-tigliaen-3-one derivatives in combination with at least one other pharmaceutically active agent. In particular embodiments, the tigliaen-3-one derivatives are 12, 13-acyl or ether derivatives and the derivative compound is delivered in a localised manner to the tumor or sarcoma. In particular embodiments, the at least one other pharmaceutically active agent is selected from an antihistamine, an anti-inflammatory agent and mixtures thereof.