公开(公告)号：US20220193023A1

公开(公告)日：2022-06-23

申请号：US17602909

申请日：2020-04-09

申请人： QBIOTICS PTY LTD

发明人： Victoria Anne GORDON ,  Paul Warren REDDELL ,  Glen Mathew BOYLE ,  Jason Kingsley CULLEN ,  Peter Gordon PARSONS

IPC分类号： A61K31/336 ,  A61P35/00 ,  A61K9/00

摘要： The present invention relates to methods of treating tumours comprising the localised administration, for example, intratumourally or topically, of an epoxytiglienone compound (as a monotherapy) to cancerous tumours to generate a systemic anticancer C abscopal (anenestic) and/or bystander effect.

公开(公告)号：US20220313648A1

公开(公告)日：2022-10-06

申请号：US17620517

申请日：2020-06-19

申请人： QBIOTICS PTY LTD

发明人： David William THOMAS ,  Paul Warren REDDELL ,  Glen Mathew BOYLE ,  Jason Kingsley CULLEN ,  Victoria Anne GORDON ,  Katja Etel HILL ,  Lydia Charlotte POWELL ,  Manon F. PRITCHARD ,  Peter G. PARSONS

IPC分类号： A61K31/336 ,  A61P31/04 ,  A61K45/06

摘要： The present invention relates to methods of dispersing biofilms comprising Gram-negative bacteria, the methods comprising exposing the biofilm to an epoxytiglienone compound or a salt thereof. Methods of treating infections comprising the localised administration, for example, topically or by injection, of an epoxytiglienone compound into or onto an established biofilm comprising Gram-negative bacteria to disrupt the structure of that biofilm and methods of preventing biofilms comprising Gram-negative bacteria forming or dispersing biofilms comprising Gram-negative biofilms that have formed on medical devices are also described.