公开(公告)号：US11510905B1

公开(公告)日：2022-11-29

申请号：US17239583

申请日：2021-04-24

申请人： Chengyuan Liang ,  Wenjing Yang ,  Qianqian Zhao ,  Liang Xin ,  Jingyi Li ,  Dan Yang ,  Ruina Bian ,  Jie Zhang ,  Yuqing Zhao ,  Han Li ,  Bin Tian ,  Yongbo Wang ,  Liang Qi ,  Gennian Mao

发明人： Chengyuan Liang ,  Wenjing Yang ,  Qianqian Zhao ,  Liang Xin ,  Jingyi Li ,  Dan Yang ,  Ruina Bian ,  Jie Zhang ,  Yuqing Zhao ,  Han Li ,  Bin Tian ,  Yongbo Wang ,  Liang Qi ,  Gennian Mao

IPC分类号： C07D233/60 ,  A61K31/4164 ,  A61P31/04

摘要： A compound with anti-drug resistant bacteria activity having the following formula (I): is disclosed. The methods of preparing the compound of formula (I) are also disclosed.

公开(公告)号：US11512049B2

公开(公告)日：2022-11-29

申请号：US17239582

申请日：2021-04-24

申请人： Qianqian Zhao ,  Yuqing Zhao ,  Dan Yang ,  Jingyi Li ,  Liang Xin ,  Ruina Bian ,  Jie Zhang ,  Han Li ,  Bin Tian ,  Yongbo Wang ,  Chengyuan Liang ,  Liang Qi ,  Gennian Mao

发明人： Qianqian Zhao ,  Yuqing Zhao ,  Dan Yang ,  Jingyi Li ,  Liang Xin ,  Ruina Bian ,  Jie Zhang ,  Han Li ,  Bin Tian ,  Yongbo Wang ,  Chengyuan Liang ,  Liang Qi ,  Gennian Mao

IPC分类号： C07C323/52 ,  A61P31/04 ,  C07C319/28

摘要： A compound with anti-drug resistant bacteria activity having the formula (I): (I) is disclosed. The methods of preparing the compound of formula (I) are also disclosed.

公开(公告)号：US11518740B2

公开(公告)日：2022-12-06

申请号：US17239575

申请日：2021-04-24

申请人： Qianqian Zhao ,  Jie Zhang ,  Liang Xin ,  Jingyi Li ,  Ruina Bian ,  Yuqing Zhao ,  Dan Yang ,  Han Li ,  Bin Tian ,  Yongbo Wang ,  Chengyuan Liang

发明人： Qianqian Zhao ,  Jie Zhang ,  Liang Xin ,  Jingyi Li ,  Ruina Bian ,  Yuqing Zhao ,  Dan Yang ,  Han Li ,  Bin Tian ,  Yongbo Wang ,  Chengyuan Liang

IPC分类号： C07C323/52 ,  C07C319/20

摘要： A compound with anti-drug resistant bacteria activity having the following formula (I): is disclosed. The methods of preparing the compound of formula (I) are also disclosed.

公开(公告)号：US11872202B2

公开(公告)日：2024-01-16

申请号：US17695741

申请日：2022-03-15

申请人： Chengyuan Liang ,  Xiuding Yang ,  Liang Xin ,  Juan Xia ,  Yuqing Zhao ,  Jie Zhang ,  Lei Tian ,  Jingyi Li ,  Shaojun Zhang ,  Qianqian Zhao

发明人： Chengyuan Liang ,  Xiuding Yang ,  Liang Xin ,  Juan Xia ,  Yuqing Zhao ,  Jie Zhang ,  Lei Tian ,  Jingyi Li ,  Shaojun Zhang ,  Qianqian Zhao

IPC分类号： A61K31/216 ,  A61P31/04

CPC分类号： A61K31/216 ,  A61P31/04

摘要： A pleuromutilin cinnamic acid ester compound with activities against antibiotic-resistant infections having the following formula (I)




R1, R2, R3, R4 and R5 are independently hydrogen, halogen, nitro, cyano, methoxy, trifluoromethyl, benzyloxy, aryl or dimethylamino.

公开(公告)号：US20240228673A9

公开(公告)日：2024-07-11

申请号：US18163103

申请日：2023-02-01

申请人： Yinjun HOU ,  Hua Li ,  Qian Gao ,  Yongbo Wang ,  Xiuding Yang ,  Yue Gao ,  Yuqing Zhao ,  Jie Zhang ,  Chengyuan Liang

发明人： Yinjun HOU ,  Hua Li ,  Qian Gao ,  Yongbo Wang ,  Xiuding Yang ,  Yue Gao ,  Yuqing Zhao ,  Jie Zhang ,  Chengyuan Liang

IPC分类号： C08B37/00 ,  C12P19/04

CPC分类号： C08B37/0024 ,  C08B37/0003 ,  C12P19/04

摘要： The invention provides a preparation method of high-content Ganoderma lucidum β-glucan and an efficient and rapid detection method thereof. The preparation method comprises ethanol-trypsin pretreatment of Ganoderma lucidum fruiting body in combination with ultrasonic-assisted alkaline hydrothermal extraction of β-glucan from Ganoderma lucidum, and purifying β-glucan by DEAE Sephadex A-25 Sephadex column chromatography using NAOH solution as a mobile phase, to obtain high purity (≥90%) of Ganoderma lucidum β-glucan. The detection method comprises placing the extracted β-glucan in an autoclave and performing hydrolysis with β-(1,3)-exo-glucanase and β-glucosidase, and detecting and analyzing the content of the prepared β-glucan by high pressure-acid enzymatic hydrolysis-HPLC method, using glucose as a standard. The preparation method of β-glucan has high extraction ratio. The efficient and rapid detection method has high sensitivity, high accuracy and good repeatability, and thus has a wide application prospect.

公开(公告)号：US20240132631A1

公开(公告)日：2024-04-25

申请号：US18163103

申请日：2023-02-01

申请人： Yinjun HOU ,  Hua Li ,  Qian Gao ,  Yongbo Wang ,  Xiuding Yang ,  Yue Gao ,  Yuqing Zhao ,  Jie Zhang ,  Chengyuan Liang

发明人： Yinjun HOU ,  Hua Li ,  Qian Gao ,  Yongbo Wang ,  Xiuding Yang ,  Yue Gao ,  Yuqing Zhao ,  Jie Zhang ,  Chengyuan Liang

IPC分类号： C08B37/00 ,  C12P19/04

CPC分类号： C08B37/0024 ,  C08B37/0003 ,  C12P19/04

摘要： The invention provides a preparation method of high-content Ganoderma lucidum β-glucan and an efficient and rapid detection method thereof. The preparation method comprises ethanol-trypsin pretreatment of Ganoderma lucidum fruiting body in combination with ultrasonic-assisted alkaline hydrothermal extraction of β-glucan from Ganoderma lucidum, and purifying β-glucan by DEAE Sephadex A-25 Sephadex column chromatography using NAOH solution as a mobile phase, to obtain high purity (≥90%) of Ganoderma lucidum β-glucan. The detection method comprises placing the extracted β-glucan in an autoclave and performing hydrolysis with β-(1,3)-exo-glucanase and β-glucosidase, and detecting and analyzing the content of the prepared β-glucan by high pressure-acid enzymatic hydrolysis-HPLC method, using glucose as a standard. The preparation method of β-glucan has high extraction ratio. The efficient and rapid detection method has high sensitivity, high accuracy and good repeatability, and thus has a wide application prospect.

公开(公告)号：US07612637B2

公开(公告)日：2009-11-03

申请号：US11822233

申请日：2007-07-03

申请人： Yuqing Zhao

发明人： Yuqing Zhao

IPC分类号： H01P1/205 ,  H01P7/04

CPC分类号： H01P1/2056

摘要： A stable and reliable built-in cross-coupled dielectric filter with temperature-independent performances and improved rectangular degree and amplitude-frequency characteristic is disclosed. The built-in cross-coupled dielectric filter comprises at least three sequentially welded coaxial dielectric resonators. Mutually coupled capacitors or mutually coupled inductors are etched on the two adjacent lateral surfaces of the adjacent coaxial dielectric resonators, respectively, with an alternate setup. The input and output ports of the built-in cross-coupled dielectric filter are positioned at the two coaxial dielectric resonators at the head and tail, respectively. The present invention is particularly applicable to the high-frequency realm such as microwave.

摘要翻译： 公开了一种稳定可靠的内置交叉耦合介质滤波器，具有温度独立性能和改进的矩形度和幅频特性。 内置交叉耦合介质滤波器包括至少三个顺序焊接的同轴介质谐振器。 相互耦合的电容器或相互耦合的电感器分别在相邻的同轴介电谐振器的两个相邻的侧表面上被分别刻蚀。 内置交叉耦合介质滤波器的输入和输出端口分别位于头部和尾部的两个同轴介质谐振器。 本发明特别适用于微波等高频领域。

公开(公告)号：US20080018418A1

公开(公告)日：2008-01-24

申请号：US11822233

申请日：2007-07-03

申请人： Yuqing Zhao

发明人： Yuqing Zhao

IPC分类号： H01P1/202

CPC分类号： H01P1/2056

摘要： A stable and reliable built-in cross-coupled dielectric filter with temperature-independent performances and improved rectangular degree and amplitude-frequency characteristic is disclosed. The built-in cross-coupled dielectric filter comprises at least three sequentially welded coaxial dielectric resonators. Mutually coupled capacitors or mutually coupled inductors are etched on the two adjacent lateral surfaces of the adjacent coaxial dielectric resonators, respectively, with an alternate setup. The input and output ports of the built-in cross-coupled dielectric filter are positioned at the two coaxial dielectric resonators at the head and tail, respectively. The present invention is particularly applicable to the high-frequency realm such as microwave.

摘要翻译： 公开了一种稳定可靠的内置交叉耦合介质滤波器，具有温度独立性能和改进的矩形度和幅频特性。 内置交叉耦合介质滤波器包括至少三个顺序焊接的同轴介质谐振器。 相互耦合的电容器或相互耦合的电感器分别在相邻的同轴介电谐振器的两个相邻的侧表面上被分别刻蚀。 内置交叉耦合介质滤波器的输入和输出端口分别位于头部和尾部的两个同轴介质谐振器。 本发明特别适用于微波等高频领域。