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1.发明申请HIV-INTEGRASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THEIR USE 失效HIV-INTEGRASE抑制剂，药物组合物及其使用方法公开(公告)号：US20070004768A1
公开(公告)日：2007-01-04
申请号：US11470301
申请日：2006-09-06
申请人： Qiyue Hu , Atsuo Kuki , Michael Plewe , Dawn Nowlin , Hai Wang , Junhu Zhang
发明人： Qiyue Hu , Atsuo Kuki , Michael Plewe , Dawn Nowlin , Hai Wang , Junhu Zhang
IPC分类号： A61K31/4745 , C07D471/14 , C07D491/14
CPC分类号： C07D471/04 , C07D471/12 , C07D471/14
摘要： Bicyclic hydroxamate compounds represented by the Formula I: are described. The bicyclic hydroxamate compounds and compositions containing those compounds may be used to inhibit or modulate an enzyme activity of HIV Integrase and to treat HIV mediated diseases and conditions.
摘要翻译： 描述由式I表示的双环氧肟酸酯化合物。 双环异羟肟酸酯化合物和含有这些化合物的组合物可用于抑制或调节HIV整合酶的酶活性并治疗HIV介导的疾病和病症。
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2.发明授权HIV-integrase inhibitors, pharmaceutical compositions, and methods for their use 失效HIV整合酶抑制剂，药物组合物及其使用方法公开(公告)号：US07135482B2
公开(公告)日：2006-11-14
申请号：US10699068
申请日：2003-10-30
申请人： Qiyue Hu , Ted William Johnson , Atsuo Kuki , Michael Bruno Plewe , Dawn Marie Nowlin , Hai Wang , Junhu Zhang
发明人： Qiyue Hu , Ted William Johnson , Atsuo Kuki , Michael Bruno Plewe , Dawn Marie Nowlin , Hai Wang , Junhu Zhang
IPC分类号： A61K31/44
CPC分类号： C07D471/04 , C07D471/12 , C07D471/14
摘要： Bicyclic hydroxamate compounds represented by the Formula I: are described. The bicyclic hydroxamate compounds and compositions containing those compounds may be used to inhibit or modulate an enzyme activity of HIV Integrase and to treat HIV mediated diseases and conditions.
摘要翻译： 描述由式I表示的双环氧肟酸酯化合物。 双环异羟肟酸酯化合物和含有这些化合物的组合物可用于抑制或调节HIV整合酶的酶活性并治疗HIV介导的疾病和病症。
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3.发明申请HIV-INTEGRASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS FOR THEIR USE 审中-公开HIV-INTEGRASE INHIBITORS，PHARMACEUTICAL COMPOSITIONS及其使用方法公开(公告)号：US20080221154A1
公开(公告)日：2008-09-11
申请号：US12043636
申请日：2008-03-06
申请人： Qiyue HU , Ted William Johnson , Atsuo Kuki , Michael Bruno Plewe , Dawn Marie Nowlin , Hai Wang , Junhu Zhang
发明人： Qiyue HU , Ted William Johnson , Atsuo Kuki , Michael Bruno Plewe , Dawn Marie Nowlin , Hai Wang , Junhu Zhang
IPC分类号： A61K31/437 , C12N9/99 , A61P31/18 , C12Q1/68
CPC分类号： C07D471/04 , C07D471/12 , C07D471/14
摘要： Bicyclic hydroxamate compounds represented by the Formula I: are described. The bicyclic hydroxamate compounds and compositions containing those compounds may be used to inhibit or modulate an enzyme activity of HIV Integrase and to treat HIV mediated diseases and conditions.
摘要翻译： 描述由式I表示的双环氧肟酸酯化合物。 双环异羟肟酸酯化合物和含有这些化合物的组合物可用于抑制或调节HIV整合酶的酶活性并治疗HIV介导的疾病和病症。
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4.发明授权HIV-Integrase inhibitors, pharmaceutical compositions and methods for their use 失效HIV整合酶抑制剂，药物组合物及其使用方法公开(公告)号：US07368571B2
公开(公告)日：2008-05-06
申请号：US11470301
申请日：2006-09-06
申请人： Qiyue Hu , Atsuo Kuki , Dawn Marie Nowlin , Michael Bruno Plewe , Hai Wang , Junhu Zhang
发明人： Qiyue Hu , Atsuo Kuki , Dawn Marie Nowlin , Michael Bruno Plewe , Hai Wang , Junhu Zhang
IPC分类号： C07D471/02 , C07D471/00
CPC分类号： C07D471/04 , C07D471/12 , C07D471/14
摘要： Bicycling hydroxamate compounds represented by the Formula I: are described. The bicyclic hydroxamate compounds and compositions containing those compounds may be used to inhibit or modulate an enzyme activity of HIV Integrase and to treat HIV mediated diseases and conditions.
摘要翻译： 描述由式I表示的骑自行车的异羟肟酸酯化合物。 双环异羟肟酸酯化合物和含有这些化合物的组合物可用于抑制或调节HIV整合酶的酶活性并治疗HIV介导的疾病和病症。
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公开(公告)号：US20060122211A1
公开(公告)日：2006-06-08
申请号：US11251344
申请日：2005-10-14
申请人： Atsuo Kuki , Xinqiang Li , Michael Plewe , Hai Wang , Junhu Zhang
发明人： Atsuo Kuki , Xinqiang Li , Michael Plewe , Hai Wang , Junhu Zhang
IPC分类号： A61K31/4745 , C07D417/14
CPC分类号： C07D471/04
摘要： Beta-carboline hydroxamic acid compounds represented by formula (I) are described. The beta-carboline hydroxamic acid compounds and compositions containing those compounds may be used to inhibit or modulate the activity of HIV integrase enzyme and to treat HIV integrase-mediated diseases and conditions.
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6.发明申请HIV-integrase inhibitors, pharmaceutical compositions, and methods for their use 失效HIV整合酶抑制剂，药物组合物及其使用方法公开(公告)号：US20050165040A1
公开(公告)日：2005-07-28
申请号：US10765227
申请日：2004-01-26
申请人： Atsuo Kuki , Xinqiang Li , Michael Plewe , Hai Wang , Junhu Zhang
发明人： Atsuo Kuki , Xinqiang Li , Michael Plewe , Hai Wang , Junhu Zhang
IPC分类号： A61P31/18 , C07D471/04 , A61K31/4745 , C07D471/14
CPC分类号： C07D471/04
摘要： Beta-carboline hydroxamic acid compounds represented by formula (I) are described. The beta-carboline hydroxamic acid compounds and compositions containing those compounds may be used to inhibit or modulate the activity of HIV integrase enzyme and to treat HIV integrase-mediated diseases and conditions.
摘要翻译： 描述了由式（I）表示的β-咔啉异羟肟酸化合物。 含有这些化合物的β-咔啉异羟肟酸化合物和组合物可用于抑制或调节HIV整合酶的活性并且用于治疗HIV整合酶介导的疾病和病症。
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公开(公告)号：US20050277662A1
公开(公告)日：2005-12-15
申请号：US11115003
申请日：2005-04-25
申请人： Klaus Dress , Qiyue Hu , Ted Johnson , Michael Plewe , Steven Tanis , Hai Wang , Anle Yang , Chunfeng Yin , Junhu Zhang
发明人： Klaus Dress , Qiyue Hu , Ted Johnson , Michael Plewe , Steven Tanis , Hai Wang , Anle Yang , Chunfeng Yin , Junhu Zhang
IPC分类号： A61K31/4745 , C07D213/00 , C07D471/02 , C07D471/04 , C07D519/00
CPC分类号： C07D471/04
摘要： The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus (“HIV”) integrase enzyme.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐和溶剂合物，它们的合成及其作为人免疫缺陷病毒（“HIV”）整合酶的调节剂或抑制剂的用途。
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公开(公告)号：US20050277661A1
公开(公告)日：2005-12-15
申请号：US11114813
申请日：2005-04-25
申请人： Klaus Dress , Qiyue Hu , Ted Johnson , Michael Plewe , Steven Tanis , Huichun Zhu , Junhu Zhang
发明人： Klaus Dress , Qiyue Hu , Ted Johnson , Michael Plewe , Steven Tanis , Huichun Zhu , Junhu Zhang
IPC分类号： A61K31/435 , A61K31/4745 , C07D471/14 , C07D491/14 , C07D519/00
CPC分类号： C07D491/14 , C07D471/14
摘要： The present invention is directed to compounds of formula (i), and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus (“HIV”) integrase enzyme.
摘要翻译： 本发明涉及式（ⅰ）化合物及其药学上可接受的盐和溶剂化物，它们的合成及其作为人类免疫缺陷病毒（“HIV”）整合酶的调节剂或抑制剂的用途。
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9.发明授权HIV integrase inhibitors, pharmaceutical compositions and methods for their use 失效HIV整合酶抑制剂，药物组合物及其使用方法公开(公告)号：US07138408B2
公开(公告)日：2006-11-21
申请号：US11251344
申请日：2005-10-14
申请人： Atsuo Kuki , Xinqiang Li , Michael Bruno Plewe , Hai Wang , Junhu Zhang
发明人： Atsuo Kuki , Xinqiang Li , Michael Bruno Plewe , Hai Wang , Junhu Zhang
IPC分类号： A61K31/437 , C07D471/12
CPC分类号： C07D471/04
摘要： Beta-carboline hydroxamic acid compounds represented by formula (I) are described. The beta-carboline hydroxamic acid compounds and compositions containing those compounds may be used to inhibit or modulate the activity of HIV integrase enzyme and to treat HIV integrase-mediated diseases and conditions.
摘要翻译： 描述了由式（I）表示的β-咔啉异羟肟酸化合物。 含有这些化合物的β-咔啉异羟肟酸化合物和组合物可用于抑制或调节HIV整合酶的活性并且用于治疗HIV整合酶介导的疾病和病症。
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10.发明授权HIV-integrase inhibitors, pharmaceutical compositions, and methods for their use 失效HIV整合酶抑制剂，药物组合物及其使用方法公开(公告)号：US07001912B2
公开(公告)日：2006-02-21
申请号：US10765227
申请日：2004-01-26
申请人： Atsuo Kuki , Xinqiang Li , Michael Bruno Plewe , Hai Wang , Junhu Zhang
发明人： Atsuo Kuki , Xinqiang Li , Michael Bruno Plewe , Hai Wang , Junhu Zhang
IPC分类号： A61K31/437 , C07D471/02 , C07D471/12
CPC分类号： C07D471/04
摘要： Beta-carboline hydroxamic acid compounds represented by formula (I) are described. The beta-carboline hydroxamic acid compounds and compositions containing those compounds may be used to inhibit or modulate the activity of HIV integrase enzyme and to treat HIV integrase-mediated diseases and conditions.
摘要翻译： 由式（I）表示的β-咔啉异羟肟酸化合物
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