公开(公告)号：US20220031720A1

公开(公告)日：2022-02-03

申请号：US17296504

申请日：2019-11-21

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Vered PADLER-KARAVANI ,  Eliran Moshe REUVEN ,  Shani LEVIATAN BEN-ARYE

IPC: A61K31/7012 ,  A61K9/127 ,  A61K39/39 ,  A61K39/00 ,  A61P35/00 ,  A61K39/395

Abstract: The present invention provides an active cancer vaccine and specifically an immunogenic compositions of membrane vesicles that serve as biomimetic nanoparticles derived from eukaryotic cell membranes that bear N-glycolylneuraminic acid glycoconjugates. These compositions can elicit beneficial immunological responses for treatment of Neu5Gc-positive tumors. The present invention provides methods of generating and using Neu5Gc-conjugated nanoparticles from eukaryotic cells membranes designated nano-ghosts.