公开(公告)号：US11470828B2

公开(公告)日：2022-10-18

申请号：US16744493

申请日：2020-01-16

Applicant: REGENERON PHARMACEUTICALS, INC.

Inventor： Meghan Drummond Samuelson ,  Brian Zambrowicz ,  Ka-Man Venus Lai ,  Charleen Hunt ,  Susannah Brydges ,  Andrew J. Murphy ,  Claudia Gonzaga-Jauregui ,  Jose Rojas ,  Nicole Alessandri-Haber ,  Robert Breese ,  Susan D. Croll

IPC: A01K67/027 ,  C12N15/85 ,  C07K14/72

Abstract: This disclosure relates to an animal model of human disease. More specifically, this disclosure relates to a rodent model of mood disorders such as unipolar depression and an anxiety disorder. Disclosed herein are genetically modified rodent animals that carry a humanized G protein-coupled receptor 156 (GPR156) gene that encodes a mutant human GPR156 protein comprising Asp at an amino acid position corresponding to position 533 in a full length wild type human GPR156 protein.

公开(公告)号：US20230123787A1

公开(公告)日：2023-04-20

申请号：US17818730

申请日：2022-08-10

Applicant: REGENERON PHARMACEUTICALS, INC.

Inventor： Meghan Drummond Samuelson ,  Brian Zambrowicz ,  Ka-Man Venus Lai ,  Charleen Hunt ,  Susannah Brydges ,  Andrew J. Murphy ,  Claudia Gonzaga-Jauregui ,  Jose Rojas ,  Nicole Alessandri-Haber ,  Robert Breese ,  Susan D. Croll

IPC: A01K67/027 ,  C12N15/85 ,  C07K14/72

Abstract: This disclosure relates to an animal model of human disease. More specifically, this disclosure relates to a rodent model of mood disorders such as unipolar depression and an anxiety disorder. Disclosed herein are genetically modified rodent animals that carry a humanized G protein-coupled receptor 156 (GPR156) gene that encodes a mutant human GPR156 protein comprising Asp at an amino acid position corresponding to position 533 in a full length wild type human GPR156 protein.

公开(公告)号：US20200229409A1

公开(公告)日：2020-07-23

申请号：US16744493

申请日：2020-01-16

Applicant: REGENERON PHARMACEUTICALS, INC.

Inventor： Meghan Drummond Samuelson ,  Brian Zambrowicz ,  Ka-Man Venus Lai ,  Charleen Hunt ,  Susannah Brydges ,  Andrew J. Murphy ,  Claudia Gonzaga-Jauregui ,  Jose Rojas ,  Nicole Alessandri-Haber ,  Robert Breese ,  Susan D. Croll

IPC: A01K67/027 ,  C12N15/85

Abstract: This disclosure relates to an animal model of human disease. More specifically, this disclosure relates to a rodent model of mood disorders such as unipolar depression and an anxiety disorder. Disclosed herein are genetically modified rodent animals that carry a humanized G protein-coupled receptor 156 (GPR156) gene that encodes a mutant human GPR156 protein comprising Asp at an amino acid position corresponding to position 533 in a full length wild type human GPR156 protein.