公开(公告)号：US10899699B2

公开(公告)日：2021-01-26

申请号：US16300436

申请日：2017-05-11

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： Bruce Blough ,  Ann Decker ,  Richard Rothman

IPC: A61K31/135 ,  A61P25/30 ,  C07C211/28

Abstract: The disclosure provides monoamine neurotransmitter releaser and/or monoamine uptake inhibitor compounds having biogenic amine transporter activity but lacking substantial activity at 5-HT2 receptor subtypes. The phenethylamine or vinylogous phenethylamine compounds of the disclosure are useful in treating diseases, conditions and/or disorders mediated by activity of one or more of the monoamine neurotransmitters.

公开(公告)号：US20190225573A1

公开(公告)日：2019-07-25

申请号：US16300436

申请日：2017-05-11

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： Bruce Blough ,  Ann Decker ,  Richard Rothman

IPC: C07C211/28 ,  A61P25/30

Abstract: The disclosure provides monoamine neurotransmitter releaser and/or monoamine uptake inhibitor compounds having biogenic amine transporter activity but lacking substantial activity at 5-HT2 receptor subtypes. The phenethylamine or vinylogous phenethylamine compounds of the disclosure are useful in treating diseases, conditions and/or disorders mediated by activity of one or more of the monoamine neurotransmitters.