公开(公告)号：US20170174633A1

公开(公告)日：2017-06-22

申请号：US15128725

申请日：2015-03-24

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： James B. THOMAS ,  Brian P. GILMOUR ,  Angela M. GIDDINGS ,  Robert W. WIETHE ,  Keith R. WARNER ,  Srinivas OLEPU

IPC: C07D231/22 ,  A61K31/415

CPC classification number: C07D231/22 ,  A61K31/415 ,  C07D231/14 ,  C07D401/04

Abstract: This invention relates generally to the discovery of pyrazole compounds selective for the neurotensin receptor 2 (NTR2) and uses thereof.

公开(公告)号：US20160095854A1

公开(公告)日：2016-04-07

申请号：US14968258

申请日：2015-12-14

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： Frank I. CARROLL ,  Juan P. CUEVA ,  James B. THOMAS ,  S. Wayne MASCARELLA ,  Scott P. RUNYON

IPC: A61K31/495 ,  A61K31/496

CPC classification number: A61K31/495 ,  A61K31/496 ,  C07D241/04 ,  C07D295/096 ,  C07D401/12

Abstract: Provided are opioid receptor antagonists represented by the formula (I): where R, Y3, R1, R2, R3, R4 and R5 are as defined herein.

Abstract translation: 提供由式（I）表示的阿片受体拮抗剂：其中R，Y 3，R 1，R 2，R 3，R 4和R 5如本文所定义。