公开(公告)号：US09701670B2

公开(公告)日：2017-07-11

申请号：US14422158

申请日：2013-08-16

申请人： RESPIVERT LIMITED ,  TOPIVERT PHARMA LIMITED

发明人： Claire Anne Marie Cariou ,  Catherine Elisabeth Charron ,  Euan Alexander Fraser Fordyce ,  Daniel Hamza ,  Matthew Colin Thor Fyfe ,  Kazuhiro Ito ,  John King-Underwood ,  Peter John Murray ,  Stuart Thomas Onions ,  Stephen Malcolm Thom ,  Hayley Tegan Angela Watson ,  Jonathan Gareth Williams

IPC分类号： A61K31/506 ,  A61K31/5377 ,  C07D409/14 ,  C07D403/12 ,  C07D401/14 ,  C07D401/12 ,  A61K45/06 ,  C07D405/14

CPC分类号： C07D409/14 ,  A61K31/506 ,  A61K31/5377 ,  A61K45/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14

摘要： There are provided compounds of formula I, wherein R, R1, Ra, Rb, Q, X and Y have meanings given in the description, which compounds have antiinflammatory activity (e.g., through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.

公开(公告)号：US20150218137A1

公开(公告)日：2015-08-06

申请号：US14422158

申请日：2013-08-16

申请人： RESPIVERT LIMITED ,  TOPIVERT PHARMA LIMITED

发明人： Claire Anne Marie Cariou ,  Catherine Elisabeth Charron ,  Euan Alexander Fraser Fordyce ,  Daniel Hamza ,  Matthew Colin Thor Fyfe ,  Kazuhiro Ito ,  John King-Underwood ,  Peter John Murray ,  Stuart Thomas Onions ,  Stephen Malcolm Thom ,  Hayley Tegan Angela Watson ,  Jonathan Gareth Williams

IPC分类号： C07D409/14 ,  A61K31/5377 ,  C07D405/14 ,  C07D403/12 ,  A61K31/506 ,  C07D401/14 ,  C07D401/12 ,  A61K45/06

CPC分类号： C07D409/14 ,  A61K31/506 ,  A61K31/5377 ,  A61K45/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14

摘要： There are provided compounds of formula I, wherein R, R1, Ra, Rb, Q, X and Y have meanings given in the description, which compounds have antiinflammatory activity (e.g., through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.

摘要翻译： 提供了式I化合物，其中R，R 1，R a，R b，Q，X和Y具有说明书中给出的含义，哪些化合物具有抗炎活性（例如，通过抑制下列成员中的一个或多个： p38丝裂原活化蛋白激酶; Syk激酶;以及Src家族酪氨酸激酶的成员），并用于治疗，包括药物组合，特别是治疗炎性疾病，包括肺，眼和肠的炎性疾病 。