公开(公告)号：US20220008303A1

公开(公告)日：2022-01-13

申请号：US17294677

申请日：2019-11-20

Applicant: RHODIA OPERATIONS

Inventor： Howard PROKOP ,  Céline ORIZET ,  Ali SAHOUANE ,  Hocine KABIR ,  Galder CRISTOBAL

IPC: A61K8/37 ,  A61K8/42

Abstract: The present invention relates to a sulfate-free aqueous concentrate comprising at least: (i) at least 25% by weight of opacifier particles selected from C16-C22 fatty acid, C16-C22 fatty alcohol, mono-, di- and tri-C16-C22 esters of glycerol, mono- and di-C16-C22 esters of ethylene glycol, diethylene glycol and triethylene glycol, C16-C22 fatty acid alkanolamides and mixtures thereof, with said particles are having a median diameter ranging from 1 to 15 μm; (ii) an amphoteric or zwitterionic surfactant, (iii) water, with the total amount of surfactants in said aqueous concentrate ranging from 0.5 to 15% by weight, relative to the total weight of the aqueous concentrate. It also relates to the use of such an aqueous concentrate as an opacifier. The aqueous concentrate of the invention may be used as an opacifier in a composition, to replace at least some of a styrene opacifier or titanium dioxide in said composition.

公开(公告)号：US20140364619A1

公开(公告)日：2014-12-11

申请号：US14301576

申请日：2014-06-11

Applicant: RHODIA OPERATIONS

Inventor： Laurianne TIMBART ,  Nemesio MARTINEZ-CASTRO ,  James WOODS ,  Howard PROKOP ,  Rastko VUKOV

IPC: C07D233/32

CPC classification number: C07D233/32

Abstract: Transesterification processes for producing a compound of formula (I) wherein R1 is H or a methyl group, A and B are each, independently, a linear or branched C2-C5 alkylene group, comprising reacting: an acrylate or methacrylate of formula (II) wherein R1 is H or a methyl group and R2 is a C1-C4 alkyl group, with a compound of formula (III) wherein the reaction is performed: (i) in the presence of calcium oxide and calcium hydroxide, and (ii) wherein the molar ratio of the compounds of formula (II) to formula (III) is less than 4:1 or 3:1 respectively.

Abstract translation: 制备其中R 1为H或甲基的式（I）化合物的酯交换方法，A和B各自独立地为直链或支链C 2 -C 5亚烷基，包括使式（II）的丙烯酸酯或甲基丙烯酸酯反应： 其中R1是H或甲基，R2是C1-C4烷基，其中进行反应的式（III）化合物：（i）在氧化钙和氢氧化钙的存在下，和（ii）其中 式（II）化合物与式（III）的摩尔比分别小于4:1或3:1。