公开(公告)号：US20100111979A1

公开(公告)日：2010-05-06

申请号：US12649179

申请日：2009-12-29

申请人： RICHARD WEBER ,  XIAO FENG ,  ORIT FOORD ,  LARRY GREEN ,  JEAN M. GUDAS ,  BRUCE KEYT ,  YING LIU ,  PALANISWAMI RATHANASWAMI ,  ROBERT RAYA ,  XIAO DONG YANG ,  JOSE CORVALAN ,  IAN FOLTZ ,  XIAO-CHI JIA ,  JASPAL S. KANG ,  CHADWICK T. KING ,  SCOTT L. KLAKAMP ,  QIAOJUAN JANE SU

发明人： RICHARD WEBER ,  XIAO FENG ,  ORIT FOORD ,  LARRY GREEN ,  JEAN M. GUDAS ,  BRUCE KEYT ,  YING LIU ,  PALANISWAMI RATHANASWAMI ,  ROBERT RAYA ,  XIAO DONG YANG ,  JOSE CORVALAN ,  IAN FOLTZ ,  XIAO-CHI JIA ,  JASPAL S. KANG ,  CHADWICK T. KING ,  SCOTT L. KLAKAMP ,  QIAOJUAN JANE SU

IPC分类号： A61K39/395 ,  C07K16/18 ,  C12N5/02

CPC分类号： C07K16/30 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6897 ,  A61K2039/505 ,  B82Y5/00 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/77 ,  C07K2317/92 ,  Y10S435/81

摘要： The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.

摘要翻译： 本发明涉及新型抗体，特别是针对表皮生长因子受体的缺失突变体的抗体，特别涉及III型缺失突变体EGFRvIII的抗体。 本发明还涉及针对表皮生长因子受体，特别是EGFRvIII的缺失突变体的人单克隆抗体。 还提供了这种抗体的诊断和治疗制剂及其免疫偶联物。