公开(公告)号：US20130210810A1

公开(公告)日：2013-08-15

申请号：US13718632

申请日：2012-12-18

Applicant: Rigel Pharmaceuticals, Inc.

Inventor： Rajinder Singh ,  Hui Li ,  Haoran Zhao ,  Rao Kolluri ,  Kin Tso ,  John Ramphal ,  Shihai Gu ,  Carlos Valdez ,  Jing Zhang ,  Emily Stauffer ,  Matthew Duncton ,  Salvador Alvarez

IPC: A61K31/506 ,  A61K31/55 ,  A61K31/538 ,  A61K31/5377

CPC classification number: A61K31/506 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/55 ,  C07D401/12 ,  C07D401/14 ,  C07D413/12

Abstract: This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

公开(公告)号：US09453028B2

公开(公告)日：2016-09-27

申请号：US14754415

申请日：2015-06-29

Applicant: Rigel Pharmaceuticals, Inc.

Inventor： Haoran Zhao ,  Rao Kolluri ,  Carlos Valdez ,  Kin Tso ,  Rajinder Singh ,  John Ramphal

IPC: C07D345/00 ,  C07D517/00 ,  C07D498/04 ,  C07D498/14 ,  A61K31/5383

CPC classification number: C07D498/04 ,  A61K31/5383 ,  C07D498/14

Abstract: This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

公开(公告)号：US20150376203A1

公开(公告)日：2015-12-31

申请号：US14754415

申请日：2015-06-29

Applicant: Rigel Pharmaceuticals, Inc.

Inventor： Haoran Zhao ,  Rao Kolluri ,  Carlos Valdez ,  Kin Tso ,  Rajinder Singh ,  John Ramphal

IPC: C07D498/04

CPC classification number: C07D498/04 ,  A61K31/5383 ,  C07D498/14

Abstract: This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

Abstract translation: 本公开涉及可用作蛋白激酶C（PKC）的抑制剂的化合物，因此可用于治疗通过PKC的活性介导或维持的多种疾病和病症。 本公开还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。

公开(公告)号：US09149475B2

公开(公告)日：2015-10-06

申请号：US13718632

申请日：2012-12-18

Applicant: Rigel Pharmaceuticals, Inc.

Inventor： Rajinder Singh ,  Hui Li ,  Haoran Zhao ,  Rao Kolluri ,  Kin Tso ,  John Ramphal ,  Shihai Gu ,  Carlos Valdez ,  Jing Zhang ,  Emily Stauffer ,  Matthew Duncton ,  Salvador Alvarez

IPC: A61K31/506 ,  A61K31/55 ,  A61K31/538 ,  A61K31/5377 ,  C07D401/12 ,  C07D401/14 ,  C07D413/12

CPC classification number: A61K31/506 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/55 ,  C07D401/12 ,  C07D401/14 ,  C07D413/12

Abstract: This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

公开(公告)号：US09095593B2

公开(公告)日：2015-08-04

申请号：US13760666

申请日：2013-02-06

Applicant: Rigel Pharmaceuticals, Inc.

Inventor： Haoran Zhao ,  Rao Kolluri ,  Carlos Valdez ,  Kin Tso ,  Rajinder Singh ,  John Ramphal

IPC: C07D345/00 ,  C07D517/00 ,  A61K31/5383 ,  C07D498/04 ,  C07D498/14

CPC classification number: C07D498/04 ,  A61K31/5383 ,  C07D498/14

Abstract: This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

公开(公告)号：US20130143875A1

公开(公告)日：2013-06-06

申请号：US13760666

申请日：2013-02-06

Applicant: RIGEL PHARMACEUTICALS, INC.

Inventor： Haoran Zhao ,  Rao Kolluri ,  Carlos Valdez ,  Kin Tso ,  Rajinder Singh ,  John Ramphal

IPC: A61K31/5383

CPC classification number: C07D498/04 ,  A61K31/5383 ,  C07D498/14

Abstract: This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.