公开(公告)号：US20160159905A1

公开(公告)日：2016-06-09

申请号：US14958053

申请日：2015-12-03

Applicant: RINAT NEUROSCIENCE CORP.

Inventor： Yasmina Noubia ABDICHE ,  Helen Kim CHO ,  Weihsien HO ,  Karen Ute JOOSS ,  Arvind RAJPAL ,  Sawsan YOUSSEF

IPC: C07K16/28 ,  A61K39/39 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06

CPC classification number: A61K39/39 ,  A61K39/0011 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2039/53 ,  A61K2039/545 ,  C07K16/2818 ,  C07K16/2878 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/55 ,  C07K2317/74 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  A61K2300/00

Abstract: The present invention provides antagonizing antibodies that bind to programmed cell death protein 1 (PD-1) and methods of using same. The anti-PD-1 antibodies can be used therapeutically alone or in combination with other therapeutics to treat cancer and other diseases.

Abstract translation: 本发明提供了结合程序性细胞死亡蛋白1（PD-1）的拮抗性抗体及其使用方法。 抗PD-1抗体可以治疗性地单独使用或与其它治疗剂组合用于治疗癌症和其它疾病。

公开(公告)号：US20220332850A1

公开(公告)日：2022-10-20

申请号：US17846933

申请日：2022-06-22

Applicant: RINAT NEUROSCIENCE CORP.

Inventor： Weihsien HO ,  Jaume PONS ,  Arvind RAJPAL ,  Pavel STROP

IPC: C07K16/46 ,  C07K16/28 ,  C07K16/30

Abstract: The present invention relates to engineered heteromultimeric proteins, and more specifically, to methods for producing and purifying heterodimeric proteins, such as bispecific antibodies and other heterodimeric proteins comprising immunoglubulin-like hinge sequences. Methods for producing and purifying such engineered heterodimeric proteins and their use in diagnostics and therapeutics are also provided.

公开(公告)号：US20190100603A1

公开(公告)日：2019-04-04

申请号：US16157951

申请日：2018-10-11

Applicant: RINAT NEUROSCIENCE CORP.

Inventor： Weihsien HO ,  Jaume PONS ,  Arvind RAJPAL ,  Pavel STROP

IPC: C07K16/46 ,  C07K16/28 ,  C07K16/30 ,  A61K39/00

Abstract: The present invention relates to engineered heteromultimeric proteins, and more specifically, to methods for producing and purifying heterodimeric proteins, such as bispecific antibodies and other heterodimeric proteins comprising immunoglobulin-like hinge sequences. Methods for producing and purifying such engineered heterodimeric proteins and their use in diagnostics and therapeutics are also provided.

公开(公告)号：US20170058054A1

公开(公告)日：2017-03-02

申请号：US15351275

申请日：2016-11-14

Applicant: RINAT NEUROSCIENCE CORP.

Inventor： Weihsien HO ,  Jaume PONS ,  Arvind RAJPAL ,  Pavel STROP

IPC: C07K16/46 ,  C07K16/28

CPC classification number: C07K16/468 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/2809 ,  C07K16/283 ,  C07K16/2887 ,  C07K16/30 ,  C07K16/46 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention relates to engineered heteromultimeric proteins, and more specifically, to methods for producing and purifying heterodimeric proteins, such as bispecific antibodies and other heterodimeric proteins comprising immunoglubulin-like hinge sequences. Methods for producing and purifying such engineered heterodimeric proteins and their use in diagnostics and therapeutics are also provided.

Abstract translation: 本发明涉及工程化的异源多聚体蛋白质，更具体地，涉及用于产生和纯化异二聚体蛋白质的方法，例如双特异性抗体和包含免疫球蛋白样铰链序列的其它异二聚体蛋白质。 还提供了用于生产和纯化这些工程异二聚体蛋白的方法及其在诊断和治疗中的应用。