公开(公告)号：US20150209437A1

公开(公告)日：2015-07-30

申请号：US14683579

申请日：2015-04-10

Applicant: ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Chinatsu FURUMIYA ,  Takayuki MIYANO ,  Atsuko NAKATA ,  Eri MATSUMOTO

IPC: A61K47/44 ,  A61K9/00 ,  A61K47/24

CPC classification number: A61K47/44 ,  A61K9/0048 ,  A61K9/08 ,  A61K47/02 ,  A61K47/10 ,  A61K47/24 ,  A61K47/26

Abstract: This invention relates to an aqueous ophthalmic composition comprising (A) polyoxyethylene castor oil in which the average number of moles of added ethylene oxide is 2 to 12 and (B) terpenoid. According to the present invention, an aqueous ophthalmic composition having an improved foam disappearance speed can be obtained.

Abstract translation: 本发明涉及一种水性眼用组合物，其包含（A）聚氧乙烯蓖麻油，其中加入的环氧乙烷的平均摩尔数为2至12，（B）萜类化合物。 根据本发明，可以获得具有改善的泡沫消失速度的眼用组合物。

公开(公告)号：US20140371123A1

公开(公告)日：2014-12-18

申请号：US14477502

申请日：2014-09-04

Applicant: ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Atsuko NAKATA

IPC: A61L12/14

CPC classification number: A61L12/14 ,  A61K9/0048 ,  A61K31/07 ,  A61K31/69 ,  A61K47/14 ,  A61K2300/00

Abstract: This invention relates to an aqueous ophthalmic composition comprising (A) polyoxyethylene castor oil in which the number of moles of added ethylene oxide is 2 to 30, and (B) at least one member selected from the group consisting of castor oil and vitamin A. According to the aqueous ophthalmic composition of the present invention, the defoaming time can be reduced even when foam is generated by vibration or impact.

Abstract translation: 本发明涉及一种水性眼用组合物，其包含（A）加成环氧乙烷的摩尔数为2〜30的聚氧乙烯蓖麻油，（B）选自蓖麻油和维生素A的至少一种。 根据本发明的水性眼用组合物，即使通过振动或冲击产生泡沫，也可以降低消泡时间。

公开(公告)号：US20150165051A1

公开(公告)日：2015-06-18

申请号：US14634270

申请日：2015-02-27

Applicant: ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Atsuko NAKATA ,  Eri MATSUMOTO

IPC: A61K47/46 ,  A61K47/44 ,  A61K9/00 ,  A61K47/02

CPC classification number: A61K47/46 ,  A61K9/0048 ,  A61K47/02 ,  A61K47/44

Abstract: This invention relates to an aqueous ophthalmic composition comprising (A) polyoxyethylene castor oil and (B) sesame oil. According to the aqueous ophthalmic composition of the present invention, defoaming time is reduced, preservative efficacy is enhanced and photostability is improved.

Abstract translation: 本发明涉及含有（A）聚氧乙烯蓖麻油和（B）芝麻油的水性眼用组合物。 根据本发明的水性眼用组合物，消泡时间降低，防腐效果提高，光稳定性提高。

公开(公告)号：US20140005277A1

公开(公告)日：2014-01-02

申请号：US13720734

申请日：2012-12-19

Applicant: ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Atsuko NAKATA ,  Eri MATSUMOTO

IPC: A61K47/44

CPC classification number: A61K47/46 ,  A61K9/0048 ,  A61K47/02 ,  A61K47/44

Abstract: This invention relates to an aqueous ophthalmic composition comprising (A) polyoxyethylene castor oil and (B) sesame oil. According to the aqueous ophthalmic composition of the present invention, defoaming time is reduced, preservative efficacy is enhanced and photostability is improved.

Abstract translation: 本发明涉及含有（A）聚氧乙烯蓖麻油和（B）芝麻油的水性眼用组合物。 根据本发明的水性眼用组合物，消泡时间降低，防腐效果提高，光稳定性提高。

公开(公告)号：US20140005274A1

公开(公告)日：2014-01-02

申请号：US13720799

申请日：2012-12-19

Applicant: ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Atsuko NAKATA

IPC: A61K31/07 ,  A61K47/14

CPC classification number: A61L12/14 ,  A61K9/0048 ,  A61K31/07 ,  A61K31/69 ,  A61K47/14 ,  A61K2300/00

Abstract: This invention relates to an aqueous ophthalmic composition comprising (A) polyoxyethylene castor oil in which the number of moles of added ethylene oxide is 2 to 30, and (B) at least one member selected from the group consisting of castor oil and vitamin A. According to the aqueous ophthalmic composition of the present invention, the defoaming time can be reduced even when foam is generated by vibration or impact.