公开(公告)号：US08507003B2

公开(公告)日：2013-08-13

申请号：US10507886

申请日：2003-03-14

申请人： Rafaël Jorda ,  Pierre Autant

发明人： Rafaël Jorda ,  Pierre Autant

IPC分类号： A61K9/14 ,  A61K9/22 ,  A61K9/16

CPC分类号： A61K9/2081 ,  A61K9/5073

摘要： A multi(micro)particulate tablet is provided comprising microparticles which comprise a mechanically non-deformable core of active principle (AP). The tablet is formed from reservoir microcapsules with prolonged release of the AP, which are each made up of a non-deformable core comprising AP and covered with at least one film coating controlling release of the AP in vivo. The microcapsules have a particle size of between 50 and 1000 microns and are coated with at least one outer overcoating envelope comprising at least one deformable organic constituent having a melting point of between 40° C. and 120° C. The envelope allows the prolonged release of the AP in vivo without modification of the release profile when the microcapsules are compressed to form a tablet, even for microparticles not specifically formulated for compression.

摘要翻译： 提供了包含微粒的多（微）颗粒片剂，其包含有机原理（AP）的机械不可变形核心。 片剂由具有延长AP释放的储存器微胶囊形成，其各自由包含AP的不可变形的芯构成并且覆盖有控制AP释放的至少一个膜涂层。 微胶囊具有50至1000微米的粒度，并且涂覆有至少一个外涂层外壳，其包含至少一种熔点在40℃和120℃之间的可变形有机成分。所述外壳允许延长释放 的AP，而在微胶囊被压缩形成片剂时即使对于未特别配制用于压缩的微粒也不改变释放曲线。