公开(公告)号：US06359165B1

公开(公告)日：2002-03-19

申请号：US09407283

申请日：1999-09-29

申请人： Rainer Stürmer ,  Martin Jochen Klatt ,  Armin Börmer ,  Jens Holz ,  Gudrun Voss

发明人： Rainer Stürmer ,  Martin Jochen Klatt ,  Armin Börmer ,  Jens Holz ,  Gudrun Voss

IPC分类号： C07C6974

CPC分类号： C07C67/31 ,  C07C69/675

摘要： Enantiomerically pure &bgr;-hydroxy esters are prepared by a process in which &bgr;-keto esters are reacted with hydrogen in the presence of catalysts of the formula LRuX2 where X is halogen, acetate, allyl, methallyl, 2-phenylallyl, perchlorate, trifluoroacetate, tetrafluoroborate, hexafluoroantimonate, hexafluorophosphate, hexafluoroarsenate or trichloroacetate, L is a bidentate phospholane of the formula I  where B=a bridging link with 1-5 carbon atoms between the two phosphorus atoms, R1=H, C1-C6-alkyl, aryl, alkylaryl or SiR23, R2=alkyl or aryl, m=0 or 1, R3=H or OR4, and R4=R1, with the proviso that if m=1 then R3=H and if m=0 then R3 ≠ H.

摘要翻译： 对映异构体纯的β-羟基酯是通过一种方法制备的，其中β-酮酯与式ⅠRuX2的催化剂，其中X是卤素，乙酸酯，烯丙基，甲代烯丙基，2-苯基烯丙基，高氯酸，三氟乙酸，四氟硼酸， 六氟锑酸盐，六氟磷酸盐，六氟砷酸盐或三氯乙酸盐，L是式I的二齿磷脂，其中B =两个磷原子之间具有1-5个碳原子的桥连，R1 = H，C1-C6-烷基，芳基，烷基芳基或SiR23， R2 =烷基或芳基，m = 0或1，R3 = H或OR4，R4 = R1，条件是如果m = 1，则R3 = H，如果m = 0，则R3 <