公开(公告)号：US20070239048A1

公开(公告)日：2007-10-11

申请号：US11380802

申请日：2006-04-28

申请人： Raja Ghanem ,  Robert Stadler ,  Xusheng Zhang

发明人： Raja Ghanem ,  Robert Stadler ,  Xusheng Zhang

IPC分类号： A61B5/04

CPC分类号： A61N1/3987 ,  A61B5/04011 ,  A61B5/0422 ,  A61B5/0456 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/0468 ,  A61B5/4836 ,  A61B5/686 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7239 ,  A61N1/05 ,  A61N1/3621 ,  A61N1/3925 ,  A61N1/3956 ,  Y10S128/901 ,  Y10S128/902

摘要： A method of detecting a cardiac event in a medical device that includes sensing cardiac signals from a plurality of electrodes forming a first sensing vector and a second sensing vector, determining inflections of the sensed cardiac signals, generating a pulse amplitude threshold in response to the determined inflections, and determining whether the inflections are indicative of noise in response to the determined inflections and the generated pulse amplitude threshold.

摘要翻译： 一种检测医疗装置中的心脏事件的方法，包括：感测来自形成第一感测向量和第二感测向量的多个电极的心脏信号，确定感测的心脏信号的变形，响应于所确定的心脏信号产生脉冲幅度阈值 并且确定所述变形是否响应于所确定的变形和产生的脉冲幅度阈值来指示噪声。

公开(公告)号：US20070239051A1

公开(公告)日：2007-10-11

申请号：US11380842

申请日：2006-04-28

申请人： Raja Ghanem ,  Robert Stadler ,  Xusheng Zhang

发明人： Raja Ghanem ,  Robert Stadler ,  Xusheng Zhang

IPC分类号： A61B5/04

CPC分类号： A61N1/3987 ,  A61B5/04011 ,  A61B5/0422 ,  A61B5/0456 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/0468 ,  A61B5/4836 ,  A61B5/686 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7239 ,  A61N1/05 ,  A61N1/3621 ,  A61N1/3925 ,  A61N1/3956 ,  Y10S128/901 ,  Y10S128/902

摘要： A method of detecting a cardiac event in a medical device that includes sensing cardiac signals from a plurality of electrodes forming a first sensing vector and a second sensing vector, determining whether a signal energy content metric of the sensed cardiac signals is within predetermined limits, determining whether a noise to signal ratio of the sensed cardiac signals is less than a signal to noise threshold, determining whether the sensed cardiac signals are associated with muscle noise, and determining whether a mean frequency corresponding to the sensed cardiac signals is less than a mean frequency threshold.

摘要翻译： 一种检测医疗装置中的心脏事件的方法，包括：感测来自形成第一感测向量和第二感测向量的多个电极的心脏信号，确定感测到的心脏信号的信号能量内容度量是否在预定限度内，确定 感测到的心脏信号的噪声信号比是否小于信号噪声阈值，确定感测的心脏信号是否与肌肉噪声相关联，以及确定对应于感测的心脏信号的平均频率是否小于平均频率 阈。

公开(公告)号：US20070239047A1

公开(公告)日：2007-10-11

申请号：US11380846

申请日：2006-04-28

申请人： Raja Ghanem ,  Robert Stadler ,  Xusheng Zhang

发明人： Raja Ghanem ,  Robert Stadler ,  Xusheng Zhang

IPC分类号： A61B5/04

CPC分类号： A61N1/3987 ,  A61B5/04011 ,  A61B5/0422 ,  A61B5/0456 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/0468 ,  A61B5/4836 ,  A61B5/686 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7239 ,  A61N1/05 ,  A61N1/3621 ,  A61N1/3925 ,  A61N1/3956 ,  Y10S128/901 ,  Y10S128/902

摘要： A method of detecting a cardiac event in a medical device that includes determining a first characteristic in response to cardiac signals sensed along a first sensing vector over a predetermined sensing window and in response to cardiac signals sensed along a second sensing vector over the predetermined sensing window, determining a second characteristic in response to cardiac signals sensed along the first sensing vector over the predetermined sensing window and in response to cardiac signals sensed along the second sensing vector over the predetermined sensing window, and determining a third characteristic in response to cardiac signals sensed along the first sensing vector over the predetermined sensing window and in response to cardiac signals sensed along the second sensing vector over the predetermined sensing window.

摘要翻译： 一种检测医疗设备中的心脏事件的方法，包括响应于沿着预定感测窗口沿着第一感测向量感测的心脏信号并且响应于沿着预定感测窗口沿着第二感测向量感测的心脏信号来确定第一特性 ，响应于沿着预定感测窗口沿着第一感测向量感测的心脏信号并且响应于沿着预定感测窗口沿着第二感测向量感测到的心脏信号，确定响应于感测到的心脏信号的第三特性的第二特性 沿着预定感测窗口上的第一感测向量，并且响应于沿着预定感测窗口沿着第二感测向量感测的心脏信号。

公开(公告)号：US20070239045A1

公开(公告)日：2007-10-11

申请号：US11380815

申请日：2006-04-28

申请人： Raja Ghanem ,  Robert Stadler ,  Xusheng Zhang

发明人： Raja Ghanem ,  Robert Stadler ,  Xusheng Zhang

IPC分类号： A61B5/04

CPC分类号： A61N1/3987 ,  A61B5/04011 ,  A61B5/0422 ,  A61B5/0456 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/0468 ,  A61B5/4836 ,  A61B5/686 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7239 ,  A61N1/05 ,  A61N1/3621 ,  A61N1/3925 ,  A61N1/3956 ,  Y10S128/901 ,  Y10S128/902

摘要： A method of detecting a cardiac event in a medical device that includes sensing a cardiac signal from a plurality of electrodes, determining amplitudes of the sensed cardiac signal during a predetermined sensing window, determining a noise to signal ratio corresponding to the determined amplitudes, and determining the sensed cardiac signal during the predetermined sensing window is corrupted by noise in response to the determined noise to signal ratio being greater than a noise to signal ratio threshold.

摘要翻译： 一种检测医疗装置中的心脏事件的方法，包括感测来自多个电极的心脏信号，确定在预定感测窗口期间检测到的心脏信号的幅度，确定对应于所确定的幅度的噪声信号比，以及确定 响应于所确定的噪声信号比大于噪声信号比阈值，在预定感测窗口期间感测到的心脏信号被噪声破坏。

公开(公告)号：US20070270704A1

公开(公告)日：2007-11-22

申请号：US11380794

申请日：2006-04-28

申请人： Raja Ghanem ,  Robert Stadler ,  Xusheng Zhang ,  Saul Greenhut

发明人： Raja Ghanem ,  Robert Stadler ,  Xusheng Zhang ,  Saul Greenhut

IPC分类号： A61B5/0452

CPC分类号： A61N1/3987 ,  A61B5/04011 ,  A61B5/0422 ,  A61B5/0456 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/0468 ,  A61B5/4836 ,  A61B5/686 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7239 ,  A61N1/05 ,  A61N1/3621 ,  A61N1/3925 ,  A61N1/3956 ,  Y10S128/901 ,  Y10S128/902

摘要： A method of detecting a cardiac event in a medical device that includes sensing cardiac signals from a plurality of electrodes forming a first sensing vector and a second sensing vector, and determining first heart rate estimates associated with cardiac signals sensed from the first sensing vector and cardiac signals sensed from the second sensing vector in response to a metric of heart rate associated with the sensed cardiac signals. Second heart rate estimates associated with the first sensing vector and with the second sensing vector are generated in response to the determined first heart rate estimates, and a determination is made as to whether both of the second heart rate estimates are greater than a predetermined heart rate threshold.

摘要翻译： 一种检测医疗装置中的心脏事件的方法，包括从形成第一感测向量和第二感测向量的多个电极感测心脏信号，以及确定与从第一感测向量和心脏感测的心脏信号相关联的第一心率估计 响应于与感测的心脏信号相关联的心率的度量，从第二感测向量感测的信号。 响应于确定的第一心率估计而产生与第一感测向量和第二感测向量相关联的第二心率估计，并且确定第二心率估计是否大于预定心率 阈。

公开(公告)号：US20070239049A1

公开(公告)日：2007-10-11

申请号：US11380823

申请日：2006-04-28

申请人： Raja Ghanem ,  Robert Stadler ,  Xusheng Zhang

发明人： Raja Ghanem ,  Robert Stadler ,  Xusheng Zhang

IPC分类号： A61B5/04

CPC分类号： A61N1/3987 ,  A61B5/04011 ,  A61B5/0422 ,  A61B5/0456 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/0468 ,  A61B5/4836 ,  A61B5/686 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7239 ,  A61N1/05 ,  A61N1/3621 ,  A61N1/3925 ,  A61N1/3956 ,  Y10S128/901 ,  Y10S128/902

摘要： A method of detecting a cardiac event in a medical device that includes sensing cardiac signals from a plurality of electrodes forming a first sensing vector and a second sensing vector, determining inflections of the sensed cardiac signals, generating a pulse amplitude threshold in response to the determined inflections, determining whether the sensed cardiac signals are corrupted by noise in response to the determined inflections and the generated pulse amplitude threshold, and determining, in response to the sensed cardiac signals being corrupted by noise, whether the sensed cardiac signals are both corrupted by noise and shockable.

摘要翻译： 一种检测医疗装置中的心脏事件的方法，包括：感测来自形成第一感测向量和第二感测向量的多个电极的心脏信号，确定感测的心脏信号的变形，响应于所确定的心脏信号产生脉冲幅度阈值 拐点，响应于所确定的变形和所产生的脉冲幅度阈值确定所感测到的心脏信号是否被噪声破坏，以及响应于感测到的心脏信号被噪声破坏，确定所感测的心脏信号是否被噪声破坏 并可震撼。

公开(公告)号：US20070239044A1

公开(公告)日：2007-10-11

申请号：US11380807

申请日：2006-04-28

申请人： Raja Ghanem ,  Robert Stadler ,  Xusheng Zhang

发明人： Raja Ghanem ,  Robert Stadler ,  Xusheng Zhang

IPC分类号： A61B5/04

CPC分类号： A61N1/3987 ,  A61B5/04011 ,  A61B5/0422 ,  A61B5/0456 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/0468 ,  A61B5/4836 ,  A61B5/686 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7239 ,  A61N1/05 ,  A61N1/3621 ,  A61N1/3925 ,  A61N1/3956 ,  Y10S128/901 ,  Y10S128/902

摘要： A method of detecting a cardiac event in a medical device that includes sensing cardiac signals from a plurality of electrodes forming a first sensing vector and a second sensing vector, determining whether the first sensing vector and the second sensing vector is corrupted by noise, and determining, in response to one of the first sensing vector and the second sensing vector being corrupted by noise, whether the other of the first sensing vector and the second sensing vector is one of a first cardiac event and a second cardiac event different from the first cardiac event.

摘要翻译： 一种检测医疗装置中的心脏事件的方法，包括从形成第一感测向量和第二感测向量的多个电极感测心脏信号，确定第一感测向量和第二感测向量是否被噪声破坏，以及确定 响应于被噪声破坏的第一感测矢量和第二感测矢量中的一个，第一感测矢量和第二感测矢量中的另一个是否是与第一心脏不同的第一心脏事件和第二心脏事件之一 事件。

公开(公告)号：US20070239050A1

公开(公告)日：2007-10-11

申请号：US11380830

申请日：2006-04-28

申请人： Raja Ghanem ,  Robert Stadler ,  Xusheng Zhang

发明人： Raja Ghanem ,  Robert Stadler ,  Xusheng Zhang

IPC分类号： A61B5/04

CPC分类号： A61N1/3987 ,  A61B5/04011 ,  A61B5/0422 ,  A61B5/0456 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/0468 ,  A61B5/4836 ,  A61B5/686 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7239 ,  A61N1/05 ,  A61N1/3621 ,  A61N1/3925 ,  A61N1/3956 ,  Y10S128/901 ,  Y10S128/902

摘要： A method of detecting a cardiac event that includes sensing cardiac signals from a plurality of electrodes, determining rates of change of the sensed cardiac signals, and determining a range of the sensed cardiac signals. The sensed cardiac signals are detected as being associated with the cardiac event in response to the determined rates of change and the determined range.

摘要翻译： 一种检测心脏事件的方法，其包括感测来自多个电极的心脏信号，确定所感测的心脏信号的变化速率，以及确定感测的心脏信号的范围。 根据所确定的变化速率和所确定的范围，将所感测到的心脏信号检测为与心脏事件相关联。

公开(公告)号：US20070239046A1

公开(公告)日：2007-10-11

申请号：US11380837

申请日：2006-04-28

申请人： Raja Ghanem ,  Robert Stadler ,  Xusheng Zhang

发明人： Raja Ghanem ,  Robert Stadler ,  Xusheng Zhang

IPC分类号： A61B5/04

CPC分类号： A61N1/3987 ,  A61B5/04011 ,  A61B5/0422 ,  A61B5/0456 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/0468 ,  A61B5/4836 ,  A61B5/686 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7239 ,  A61N1/05 ,  A61N1/3621 ,  A61N1/3925 ,  A61N1/3956 ,  Y10S128/901 ,  Y10S128/902

摘要： A method of detecting a cardiac event in a medical device that includes sensing cardiac signals from a plurality of electrodes forming a first sensing vector and a second sensing vector, and determining whether the sensing of cardiac signals along the first sensing vector and along the second sensing vector is corrupted by noise. If the cardiac signals sensed along both the first sensing vector and the second sensing vector are not corrupted by noise, a determination is made as to whether the cardiac signals sensed along the first sensing vector and along the second sensing vector are one of a first cardiac event and a second cardiac event. The determination of whether the cardiac signals sensed along the first sensing vector and along the second sensing vector are one of a first cardiac event and a second cardiac event is then confirmed.

摘要翻译： 一种检测医疗装置中的心脏事件的方法，包括：感测来自形成第一感测向量和第二感测向量的多个电极的心脏信号，以及确定沿着第一感测向量并沿着第二感测的心脏信号的感测 矢量被噪音破坏了。 如果沿着第一感测向量和第二感测矢量两者感测的心脏信号不被噪声破坏，则确定沿着第一感测向量和沿着第二感测向量感测的心脏信号是否是第一心脏 事件和第二次心脏事件。 然后确定沿着第一感测向量和沿着第二感测向量感测的心脏信号是否是第一心脏事件和第二心脏事件之一的确定。

公开(公告)号：US08718763B2

公开(公告)日：2014-05-06

申请号：US13353824

申请日：2012-01-19

申请人： Xiaohong Zhou ,  Robert Stadler ,  Richard N. M. Cornelussen ,  Lilian Kornet ,  Paul D. Ziegler ,  Karen J. Kleckner ,  Alberto Della Scala

发明人： Xiaohong Zhou ,  Robert Stadler ,  Richard N. M. Cornelussen ,  Lilian Kornet ,  Paul D. Ziegler ,  Karen J. Kleckner ,  Alberto Della Scala

IPC分类号： A61N1/365

CPC分类号： A61N1/36114

摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.