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    Process For Producing Enriched Fractions Containing Up To 100% Of Bacopasaponins From The Plant Materials Of Bacopa Species
    1.
    发明申请
    Process For Producing Enriched Fractions Containing Up To 100% Of Bacopasaponins From The Plant Materials Of Bacopa Species 有权
    从Bacopa物种的植物材料中生产含有高达100％的Bacopasaponins的富含级分的方法

    公开(公告)号：US20080132455A1

    公开(公告)日：2008-06-05

    申请号：US11813778

    申请日：2005-05-03

    申请人： Raju Gokaraju Ganga ,  Raju Gokaraju Rama ,  Subbaraju Gottumukala Venkata ,  Trimurtulu Golakoti ,  Sivaramakrishna Chillara

    发明人： Raju Gokaraju Ganga ,  Raju Gokaraju Rama ,  Subbaraju Gottumukala Venkata ,  Trimurtulu Golakoti ,  Sivaramakrishna Chillara

    IPC分类号： A61K31/70 ,  A61P25/28 ,  C07G3/00

    CPC分类号： A61K36/80

    摘要： This invention describes a process for producing a fraction enriched with jujubogenin and psudojujubogenin lycosides from Bacopa species, wherein the total Bacopa saponin concentration is up to 100% when estimated by HPLC method of analysis. The present invention also describes the processes for the enrichment of new compositions and individual saponin compounds from Bacopa munnieri to more than 95% purity. It further describes an analytical HPLC method for the estimation of total Bacopa saponin fraction and its use in therapeutic applications. This invention also includes two Bacopa saponin 3-O-[β-D-glucopyranosyl-(1 3)-β-D-glucopyranosyl] jujubogenin and 3-O-[β-D-glucopyranosyl-(1 3)-β-D-glucopyranosyl] pseudojujubogenin herein referred to as bacopaside N1 of general formula (1) and bacopaside N2 of general formula (2) respectively.

    摘要翻译： 本发明描述了从Bacopa物种生产富集jujubogenin和psudojujubogenin lycosides的级分的方法，其中当通过HPLC分析方法估计时，总Bacopa皂苷浓度高达100％。 本发明还描述了从Bacopa munnieri中将新组合物和单独皂苷化合物富集至纯度达95％以上的方法。 它进一步描述了用于估计总Bacopa皂角苷级分的分析型HPLC方法及其在治疗应用中的用途。 本发明还包括两种Bacopa皂角苷3-O- [β-D-吡喃葡萄糖基 - （1,3）-β-D-吡喃葡萄糖基] jujubogenin和3-O- [β-D-吡喃葡萄糖基 - （13）-β-D - 吡喃葡萄糖基]假胡椒素原，本文称为通式（1）的杆菌肽N1和通式（2）的杆菌肽N2。

    Process for producing enriched fractions containing up to 100% of bacopasaponins from the plant materials of bacopa species
    2.
    发明授权
    Process for producing enriched fractions containing up to 100% of bacopasaponins from the plant materials of bacopa species 有权
    从棒杆菌属植物材料生产含有高达100％的杆菌皂苷的富集级分的方法

    公开(公告)号：US08541381B2

    公开(公告)日：2013-09-24

    申请号：US11813778

    申请日：2005-05-03

    申请人： Raju Gokaraju Ganga ,  Raju Gokaraju Rama ,  Subbaraju Gottumukkala Venkata ,  Trimurtulu Golakoti ,  Sivaramakrishna Chillara

    发明人： Raju Gokaraju Ganga ,  Raju Gokaraju Rama ,  Subbaraju Gottumukkala Venkata ,  Trimurtulu Golakoti ,  Sivaramakrishna Chillara

    IPC分类号： A61K31/70 ,  A61K31/7028 ,  C07H17/00

    CPC分类号： A61K36/80

    摘要： This invention describes a process for producing a fraction enriched with jujubogenin and psudojujubogenin lycosides from Bacopa species, wherein the total Bacopa saponin concentration is up to 100% when estimated by HPLC method of analysis. The present invention also describes the processes for the enrichment of new compositions and individual saponin compounds from Bacopa monnieri to more than 95% purity. It further describes an analytical HPLC method for the estimation of total Bacopa saponin fraction and its use in therapeutic applications. This invention also includes two Bacopa saponin 3-O-[β-D-glucopyranosyl-(1→3)-β-D-glucopyranosyl] jujubogenin and 3-O-[β-D-glucopyranosyl-(1→3)-β-D-glucopyranosyl] pseudojujubogenin herein referred to as bacopaside N1 of general formula (1) and bacopaside N2 of general formula (2) respectively.

    摘要翻译： 本发明描述了从Bacopa物种生产富集jujubogenin和psudojujubogenin lycosides的级分的方法，其中当通过HPLC分析方法估计时，总Bacopa皂苷浓度高达100％。 本发明还描述了从Bacopa monnieri中将新组合物和单独皂苷化合物富集至95％以上纯度的方法。 它进一步描述了用于估计总Bacopa皂角苷级分的分析型HPLC方法及其在治疗应用中的用途。 本发明还包括两种Bacopa皂角苷3-O-β-D-吡喃葡萄糖基 - （1-> 3）-β-D-吡喃葡萄糖基] jujubogenin和3-O- [β-D-吡喃葡萄糖基 - （1-> 3） β-D-吡喃葡萄糖基]假胡椒素原，本文中分别称为通式（1）的杆菌肽N1和通式（2）的杆菌肽N2。