公开(公告)号：US20080193461A1

公开(公告)日：2008-08-14

申请号：US11793452

申请日：2005-12-20

申请人： Rakesh K. Jain ,  Frank Winkler ,  Ricky Tong ,  Sergey V. Kozin

发明人： Rakesh K. Jain ,  Frank Winkler ,  Ricky Tong ,  Sergey V. Kozin

IPC分类号： A61K39/395 ,  C12Q1/68 ,  A61P35/00

CPC分类号： G01N33/57407 ,  A61K2039/505 ,  C07K16/22 ,  C07K16/2863 ,  G01N2333/515

摘要： The present invention provides methods for decreasing tumor growth in a subject that rely on detecting an increase in the expression of angiopoietin-1 or a decrease in the expression of angiopoietin-2 in the tumor or in the bloodstream of the subject to detect the normalization window in tumor vasculature.

摘要翻译： 本发明提供减少受试者肿瘤生长的方法，其依赖于检测血管生成素-1的表达增加或血管生成素-2在肿瘤或受试者的血流中的表达降低以检测归一化窗口 在肿瘤脉管系统。

公开(公告)号：US20050248114A1

公开(公告)日：2005-11-10

申请号：US10842381

申请日：2004-05-10

申请人： Frank Winkler ,  Gary Winkler

发明人： Frank Winkler ,  Gary Winkler

IPC分类号： B62D21/11

CPC分类号： B62D21/11

摘要： A vehicle sub-frame assembly for supporting an after-market body part includes support members each provided with a recessed portion for receiving side exhaust pipes therethrough and directing same outwardly from the vehicle sub-frame. The present invention further includes a plurality of plates for securing the support members to the vehicle sub-frame. A cross-brace tube maintains space between the support members and a plurality of caps maintain the cross-brace tube in position during operating conditions. Rear-frame spring-perch tube connectors cooperate with the plurality of caps to fasten the cross-brace tube adjacent the support members. The present invention further includes connectors, each secured to the support members and extending rearwardly for receiving the cross-brace tube.

摘要翻译： 用于支撑售后市场主体部分的车辆子框架组件包括支撑构件，每个支撑构件设置有用于接收侧排气管的凹部，并且从车辆副框架向外引导。 本发明还包括用于将支撑构件固定到车辆子框架的多个板。 交叉支撑管在支撑构件之间保持空间，并且多个帽在操作条件期间将交叉支撑管保持在适当的位置。 后框架弹簧管连接器与多个盖配合，以将交叉支撑管紧固在支撑构件附近。 本发明还包括连接器，每个连接器固定到支撑构件上并且向后延伸以接纳交叉支撑管。