公开(公告)号：US08236859B2

公开(公告)日：2012-08-07

申请号：US12354285

申请日：2009-01-15

申请人： Ralf Siegner ,  Ursula Holtzmann ,  Julia Eckert ,  Stefan Heuser ,  Marc Winnefeld

发明人： Ralf Siegner ,  Ursula Holtzmann ,  Julia Eckert ,  Stefan Heuser ,  Marc Winnefeld

IPC分类号： A61K31/12

CPC分类号： A61Q19/007 ,  A61K8/35 ,  A61Q19/06 ,  A61Q19/08

摘要： A cosmetic or dermatological preparation which is suitable for application to skin and comprises 3-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)-propane-1-one in a concentration which is effective for at least one of increasing skin moisture content, moisturizing skin, improving the surface structure of the skin, reducing cellulite, increasing the resilience and elasticity of skin, strengthening the connective tissue of skin, and reducing stretch marks on skin. This Abstract is not intended to define the invention disclosed in the specification, nor intended to limit the scope of the invention in any way.

摘要翻译： 适用于皮肤的化妆品或皮肤病学制剂，其包含3-（4-羟基-3-甲氧基苯基）-1-（4-羟基苯基） - 丙烷-1-酮，其浓度对于至少一种 增加皮肤水分含量，保湿皮肤，改善皮肤的表面结构，减少脂肪团，增加皮肤的弹性和弹性，增强皮肤的结缔组织，并减少皮肤上的妊娠纹。 本摘要不旨在限定说明书中公开的发明，也不旨在以任何方式限制本发明的范围。

公开(公告)号：US20090209651A1

公开(公告)日：2009-08-20

申请号：US12354285

申请日：2009-01-15

申请人： Ralf SIEGNER ,  Ursula Holtzmann ,  Julia Eckert ,  Stefan Heuser ,  Marc Winnefeld

发明人： Ralf SIEGNER ,  Ursula Holtzmann ,  Julia Eckert ,  Stefan Heuser ,  Marc Winnefeld

IPC分类号： A61K31/12 ,  C07C49/255

CPC分类号： A61Q19/007 ,  A61K8/35 ,  A61Q19/06 ,  A61Q19/08

摘要： A cosmetic or dermatological preparation which is suitable for application to skin and comprises 3-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)-propane-1-one in a concentration which is effective for at least one of increasing skin moisture content, moisturizing skin, improving the surface structure of the skin, reducing cellulite, increasing the resilience and elasticity of skin, strengthening the connective tissue of skin, and reducing stretch marks on skin. This Abstract is not intended to define the invention disclosed in the specification, nor intended to limit the scope of the invention in any way.

摘要翻译： 适用于皮肤的化妆品或皮肤病学制剂，其包含3-（4-羟基-3-甲氧基苯基）-1-（4-羟基苯基） - 丙烷-1-酮，其浓度对于至少一种 增加皮肤水分含量，保湿皮肤，改善皮肤的表面结构，减少脂肪团，增加皮肤的弹性和弹性，增强皮肤的结缔组织，并减少皮肤上的妊娠纹。 本摘要不旨在限定说明书中公开的发明，也不旨在以任何方式限制本发明的范围。

公开(公告)号：US20090226446A1

公开(公告)日：2009-09-10

申请号：US12226013

申请日：2007-04-05

申请人： Celina Cziepluch ,  Jean Rommelaere ,  Marc Winnefeld

发明人： Celina Cziepluch ,  Jean Rommelaere ,  Marc Winnefeld

IPC分类号： A61K39/395 ,  C12N5/08 ,  C12N5/06 ,  A61K31/7105 ,  A61K38/02 ,  C12Q1/02 ,  G01N33/53

CPC分类号： C12N15/1136 ,  C12N15/113 ,  C12N2310/14

摘要： Disclosed is a method for inhibiting the propagation of an undesired cell population, the method comprising introducing into a cell an antagonist of Bat 3, or of a functional variant thereof, said antagonist depleting Bat 3, a functional variant thereof, in a cell of said cell population, and verifying the reduced proliferation and/or cell death in Bat 3 depleted cell populations; disclosed is further the use of a Bat 3 antagonist for the manufacture of a medicament for the treatment of diseases which are caused by the propagation of an undesired cell population.

摘要翻译： 公开了一种抑制不期望的细胞群体繁殖的方法，该方法包括向所述细胞中引入Bat 3的拮抗剂或其功能变体，所述拮抗剂在所述细胞群的细胞中消耗Bat 3，其功能性变体， 细胞群体，并验证蝙蝠3耗尽的细胞群体中减少的增殖和/或细胞死亡; 还公开了使用Bat 3拮抗剂来制造用于治疗由不想要的细胞群繁殖引起的疾病的药物。

公开(公告)号：US20080166349A1

公开(公告)日：2008-07-10

申请号：US10568356

申请日：2004-08-16

申请人： Celina Cziepluch ,  Jean Rommelaere ,  Marc Winnefeld

发明人： Celina Cziepluch ,  Jean Rommelaere ,  Marc Winnefeld

IPC分类号： A61K39/395 ,  C12N5/06 ,  A61K31/70 ,  A61P43/00 ,  A61K35/76 ,  C12Q1/02

CPC分类号： C12N15/113 ,  A61K38/00 ,  C12N2310/14

摘要： Disclosed is a method for inhibiting the propagation of an undesired cell population, the method comprising introducing into a cell an antagonist of SGT, or of a functional variant thereof, said antagonist depleting SGT, a functional variant thereof, in a cell of said cell population, and verifying the reduced proliferation and/or cell death in SGT depleted cell populations; disclosed is further the use of a SGT antagonist for the manufacture of a medicament for the treatment of diseases which are caused by the propagation of an undesired cell population.

摘要翻译： 本发明公开了一种抑制不想要的细胞群繁殖的方法，该方法包括向所述细胞中引入SGT的拮抗剂或其功能性变体，所述拮抗剂在所述细胞群的细胞中消耗SGT，其功能性变体 ，并验证SGT消耗的细胞群体中增殖和/或细胞死亡的减少; 还公开了SGT拮抗剂在制备用于治疗由不需要的细胞群的繁殖引起的疾病的药物中的应用。