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    S-dimethylarsino-thiosuccinic acid S-dimethylarsino-2-thiobenzoic acid S-(dimethylarsino) glutathione as treatments for cancer
    5.
    发明申请
    S-dimethylarsino-thiosuccinic acid S-dimethylarsino-2-thiobenzoic acid S-(dimethylarsino) glutathione as treatments for cancer 审中-公开
    S-二甲基胂基 - 硫代琥珀酸

    公开(公告)号：US20080090904A1

    公开(公告)日：2008-04-17

    申请号：US11894807

    申请日：2007-08-20

    申请人： Ralph Zingaro ,  Emil Freireich ,  Hatice Duzkale ,  Hagop Kantarjian ,  Srdan Verstovsek ,  Merida Sotelo-Lerma

    发明人： Ralph Zingaro ,  Emil Freireich ,  Hatice Duzkale ,  Hagop Kantarjian ,  Srdan Verstovsek ,  Merida Sotelo-Lerma

    IPC分类号： A61K31/285 ,  A61P35/00 ,  C07F9/66

    CPC分类号： C07F9/72

    摘要： Arsenic trioxide, an inorganic compound, is commercially available anti-cancer agent but it carries significant toxicity. Organic arsenicals, on the other hand, are much less toxic, to the extent that the methylation of inorganic arsenic in vivo into organic arsenicals has been considered a detoxification reaction. New organic arsenic derivatives have been synthesized, including S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid and S-dimethylarsino-thiobenzoic acid, and established its potent in vitro cytotoxic activity against numerous human tumor cell lines, both of solid and hematological origin, as well as against malignant blood cells from patients with leukemia. Results form a basis for the development of S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid, S-dimethylarsino-thiobenzoic acid, and other organic arsenicals as an anti-cancer therapy, combining high efficacy with very low, if any, toxicity.

    摘要翻译： 三氧化二砷（无机化合物）是市售的抗癌剂，但具有显着的毒性。 另一方面，有机砷的毒性远低于体内无机砷甲基化成有机砷被认为是解毒反应的程度。 已经合成了新的有机砷衍生物，包括S-二甲基胂基 - 谷胱甘肽，S-二甲基胂基 - 硫代琥珀酸和S-二甲基胂基 - 硫代苯甲酸，并建立了其对许多人类肿瘤细胞系的有效体外细胞毒活性，包括固体和血液学起源 ，以及来自白血病患者的恶性血细胞。 结果形成了开发S-二甲基胂基 - 谷胱甘肽，S-二甲基胂基 - 硫代琥珀酸，S-二甲基胂基 - 硫代苯甲酸和其他有机砷作为抗癌治疗的基础，将高效率与非常低（如果有的话）毒性相结合 。

    S-dimethylarsino-thiosuccinic acid S-dimethylarsino-2-thiobenzoic acid S-(dimethylarsino) glutathione as treatments for cancer
    7.
    发明授权
    S-dimethylarsino-thiosuccinic acid S-dimethylarsino-2-thiobenzoic acid S-(dimethylarsino) glutathione as treatments for cancer 有权
    S-二甲基胂基 - 硫代琥珀酸S-二甲基胂基-2-硫代苯甲酸S-（二甲基胂）谷胱甘肽作为癌症治疗

    公开(公告)号：US07619000B2

    公开(公告)日：2009-11-17

    申请号：US11349043

    申请日：2006-02-06

    申请人： Ralph A. Zingaro ,  Emil J. Freireich ,  Hatice Duzkale ,  Hagop Kantarjian ,  Srdan Verstovsek ,  Merida Sotelo-Lerma

    发明人： Ralph A. Zingaro ,  Emil J. Freireich ,  Hatice Duzkale ,  Hagop Kantarjian ,  Srdan Verstovsek ,  Merida Sotelo-Lerma

    IPC分类号： A61K31/285 ,  A61K33/36 ,  C07F9/00

    CPC分类号： C07F9/72

    摘要： Arsenic trioxide, an inorganic compound, is commercially available anti-cancer agent but it carries significant toxicity. Organic arsenicals, on the other hand, are much less toxic, to the extent that the methylation of inorganic arsenic in vivo into organic arsenicals has been considered a detoxification reaction. New organic arsenic derivatives have been synthesized, including S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid and S-dimethylarsino-thiobenzoic acid, and established its potent in vitro cytotoxic activity against numerous human tumor cell lines, both of solid and hematological origin, as well as against malignant blood cells from patients with leukemia. Results form a basis for the development of S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid, S-dimethylarsino-thiobenzoic acid, and other organic arsenicals as an anti-cancer therapy, combining high efficacy with very low, if any, toxicity.

    摘要翻译： 三氧化二砷（无机化合物）是市售的抗癌剂，但具有显着的毒性。 另一方面，有机砷的毒性远低于体内无机砷甲基化成有机砷被认为是解毒反应的程度。 已经合成了新的有机砷衍生物，包括S-二甲基胂基 - 谷胱甘肽，S-二甲基胂基 - 硫代琥珀酸和S-二甲基胂基 - 硫代苯甲酸，并建立了其对许多人类肿瘤细胞系的有效体外细胞毒活性，包括固体和血液学起源 ，以及来自白血病患者的恶性血细胞。 结果形成了开发S-二甲基胂基 - 谷胱甘肽，S-二甲基胂基 - 硫代琥珀酸，S-二甲基胂基 - 硫代苯甲酸和其他有机砷作为抗癌治疗的基础，将高效率与非常低（如果有的话）毒性相结合 。

    S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer
    8.
    发明授权
    S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer 有权
    S-二甲基胂基 - 硫代琥珀酸s-二甲基胂基-2-硫代苯甲酸s-（二甲基胂）谷胱甘肽作为癌症治疗

    公开(公告)号：US06911471B2

    公开(公告)日：2005-06-28

    申请号：US10337969

    申请日：2003-01-07

    申请人： Ralph A. Zingaro ,  Emil J. Freireich ,  Hatice Duzkale ,  Hagop Kantarjian ,  Srdan Verstovsek ,  Merida Sotelo-Lerma

    发明人： Ralph A. Zingaro ,  Emil J. Freireich ,  Hatice Duzkale ,  Hagop Kantarjian ,  Srdan Verstovsek ,  Merida Sotelo-Lerma

    IPC分类号： A61K38/00 ,  A61K31/203 ,  A61K31/285 ,  A61P35/00 ,  A61P35/02 ,  C07F9/72 ,  C07F9/74 ,  C07F9/78 ,  A61K33/36 ,  C07F9/70

    CPC分类号： C07F9/72

    摘要： Arsenic trioxide, an inorganic compound, is commercially available anti-cancer agent but it carries significant toxicity. Organic arsenicals, on the other hand, are much less toxic, to the extent that the methylation of inorganic arsenic in vivo into organic arsenicals has been considered a detoxification reaction. New organic arsenic derivatives have been synthesized, including S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid and S-dimethylarsino-thiobenzoic acid, and established its potent in vitro cytotoxic activity against numerous human tumor cell lines, both of solid and hematological origin, as well as against malignant blood cells from patients with leukemia. Results form a basis for the development of S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid, S-dimethylarsino-thiobenzoic acid, and other organic arsenicals as an anti-cancer therapy, combining high efficacy with very low, if any, toxicity.

    摘要翻译： 三氧化二砷（无机化合物）是市售的抗癌剂，但具有显着的毒性。 另一方面，有机砷的毒性远低于体内无机砷甲基化成有机砷被认为是解毒反应的程度。 已经合成了新的有机砷衍生物，包括S-二甲基胂基 - 谷胱甘肽，S-二甲基胂基 - 硫代琥珀酸和S-二甲基胂基 - 硫代苯甲酸，并建立了其对许多人类肿瘤细胞系的有效体外细胞毒活性，包括固体和血液学起源 ，以及来自白血病患者的恶性血细胞。 结果形成了开发S-二甲基胂基 - 谷胱甘肽，S-二甲基胂基 - 硫代琥珀酸，S-二甲基胂基 - 硫代苯甲酸和其他有机砷作为抗癌治疗的基础，将高效率与非常低（如果有的话）毒性相结合 。

    S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer
    9.
    发明授权
    S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer 有权
    S-二甲基胂基 - 硫代琥珀酸s-二甲基胂基-2-硫代苯甲酸s-（二甲基胂）谷胱甘肽作为癌症治疗

    公开(公告)号：US06995188B2

    公开(公告)日：2006-02-07

    申请号：US11035178

    申请日：2005-01-13

    申请人： Ralph A. Zingaro ,  Emil J. Freireich ,  Hatice Duzkale ,  Hagop Kantarjian ,  Srdan Verstovsek ,  Merida Sotelo-Lerma

    发明人： Ralph A. Zingaro ,  Emil J. Freireich ,  Hatice Duzkale ,  Hagop Kantarjian ,  Srdan Verstovsek ,  Merida Sotelo-Lerma

    IPC分类号： A61K31/285 ,  A61K33/36 ,  C07F9/70

    CPC分类号： C07F9/72

    摘要： Arsenic trioxide, an inorganic compound, is commercially available anti-cancer agent but it carries significant toxicity. Organic arsenicals, on the other hand, are much less toxic, to the extent that the methylation of inorganic arsenic in vivo into organic arsenicals has been considered a detoxification reaction. New organic arsenic derivatives have been synthesized, including S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid and S-dimethylarsino-thiobenzoic acid, and established its potent in vitro cytotoxic activity against numerous human tumor cell lines, both of solid and hematological origin, as well as against malignant blood cells from patients with leukemia. Results form a basis for the development of S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid, S-dimethylarsino-thiobenzoic acid, and other organic arsenicals as an anti-cancer therapy, combining high efficacy with very low, if any, toxicity.

    摘要翻译： 三氧化二砷（无机化合物）是市售的抗癌剂，但具有显着的毒性。 另一方面，有机砷的毒性远低于体内无机砷甲基化成有机砷被认为是解毒反应的程度。 已经合成了新的有机砷衍生物，包括S-二甲基胂基 - 谷胱甘肽，S-二甲基胂基 - 硫代琥珀酸和S-二甲基胂基 - 硫代苯甲酸，并建立了其对许多人类肿瘤细胞系的有效体外细胞毒活性，包括固体和血液学起源 ，以及来自白血病患者的恶性血细胞。 结果形成了开发S-二甲基胂基 - 谷胱甘肽，S-二甲基胂基 - 硫代琥珀酸，S-二甲基胂基 - 硫代苯甲酸和其他有机砷作为抗癌治疗的基础，将高效率与非常低（如果有的话）毒性相结合 。